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Serum vitamin E and the sickling status in children with sickle cell anaemia

Serum vitamin E and the sickling status in children with sickle cell anaemia

East African Medical Journal 67(10): 720-725

Serum vitamin E levels were determined on 62 children with sickle cell anaemia and 35 age-matched controls. Among the sicklers, the irreversibly sickled cell counts were done and correlated with serum vitamin E levels. There was a significant difference in serum vitamin E values (P < 0.001), the sickle cell anaemia patients showing a deficiency with 27% of them deficient as against 2.9% of controls. The vitamin E deficient sicklers were also found to have significantly higher irreversibly sickled counts (P < 0.02), indicating that vitamin E is an important inhibitor of the irreversibly sickled cell formation.

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Accession: 002219892

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PMID: 2282895

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