Sterol 14 alpha -demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha -demethylase (P-45014DM) of yeast
Sterol 14 alpha -demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha -demethylase (P-45014DM) of yeast
Yoshida, Y.; Aoyama, Y.
Biochemical Society Transactions 19(3): 778-782
1991
Results from a series of experiments concerning the architecture of the active centre of P-45014DM of Saccharomyces cerevisiae as a model enzyme are summarized. It is suggested that such information would be useful for designing azole antifungal agents selective for P-45014DM.