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Sterol 14 alpha -demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha -demethylase (P-45014DM) of yeast



Sterol 14 alpha -demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha -demethylase (P-45014DM) of yeast



Biochemical Society Transactions 19(3): 778-782



Results from a series of experiments concerning the architecture of the active centre of P-45014DM of Saccharomyces cerevisiae as a model enzyme are summarized. It is suggested that such information would be useful for designing azole antifungal agents selective for P-45014DM.

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Accession: 002228887

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PMID: 1783215


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