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The cysteine-rich protein gene family of Giardia lamblia: loss of the CRP170 gene in an antigenic variant

The cysteine-rich protein gene family of Giardia lamblia: loss of the CRP170 gene in an antigenic variant

Molecular and Cellular Biology 12(3): 1194-1201

Almost a full length of G. lamblia cDNA was cloned as well as genomic clones for a 170 000 MW surface antigen (CRP170) from the WBA6 cloned isolate. In addition, a cDNA clone was isolated from the WB1269 line (expressing CRP72), an antigenic variant which was derived from WBA6. Sequence analysis of the CRP170 and CRP72 genes revealed marked C-terminal amino acid homology, suggesting a conserved functional role such as membrane anchoring.

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Accession: 002244954

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PMID: 1545800

DOI: 10.1128/MCB.12.3.1194

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