EurekaMag.com logo
+ Translate

The effects of famotidine, ranitidine and magnesium hydroxide/aluminium hydroxide on gastric fluid pH in adult horses


, : The effects of famotidine, ranitidine and magnesium hydroxide/aluminium hydroxide on gastric fluid pH in adult horses. Equine Veterinary Journal 24(Supplement 11): 52-55

Gastric fluid pH was measured in five adult horses following nasogastric administration of famotidine, 0.5, 1.0, and 2.0 mg/kg bodyweight (bwt); ranitidine, 4.4 and 6.6 mg/kg bwt and an antacid containing magnesium hydroxide (40 mg/ml) and aluminium hydroxide (45 mg/ml), 120 and 180 ml. Fluid was aspirated through a 16 French nasogastric feeding tube at 15 min intervals, and pH was measured using a pH meter. Basal gastric fluid pH was measured at 20 min intervals for 6 h in each horse and, with the exception of two measurements of 4.66 and 4.17, ranged from 1.42 to 2.41, with a mean pH of 1.88 +/- 0.18. The response to both ranitidine and famotidine was variable between horses and between dosages. The mean gastric fluid pH values following administration of a single dose of famotidine or ranitidine were famotidine, 0.5 mg/kg bwt, 3.63 +/- 1.72; famotidine, 1.0 mg/kg bwt, 3.41 +/- 1.40; famotidine, 2.0 mg/kg bwt, 4.18 +/- 2.06; ranitidine, 4.4 mg/kg bwt, 4.07 +/- 1.25; ranitidine 6.6 mg/kg bwt, 5.34 +/- 1.12. Differences in mean gastric fluid pH between famotidine dose levels and between ranitidine dose levels were not significant (P > 0.10). Gastric fluid pH increased to greater than 6 in three horses receiving 0.5 mg/kg bwt, five horses receiving 1.0 mg/kg bwt and three horses receiving 2.0 mg/kg bwt famotidine. Gastric fluid pH increased to greater than 6 in each of the five horses receiving 6.6 mg/kg bwt ranitidine and in four of five horses receiving 4.4 mg/kg bwt ranitidine. During the 6 h post administration, ranitidine tended to increase gastric fluid pH greater than 6 longer (166 +/- 106 mins) than famotidine (98 +/- 110 mins) and this difference was nearly significant (P = 0.054). The response to antacid was variable and consistently short-lived. The mean gastric fluid pH values for 6 h after administration of 120 ml or 180 ml were 2.42 +/- 0.71 and 2.44 +/- 0.47, respectively. Gastric fluid pH increased to greater than 6 in only two horses, for 15 and 30 mins, respectively. The increase in gastric fluid pH was significantly greater for ranitidine (P < 0.001) and famotidine (P < 0.02) than for antacid. The duration of the effect was significantly longer for ranitidine doses (P < 0.001) and nearly so for famotidine doses (P < 0.055) than for antacid.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002249135

PMID: 9109961

DOI: 10.1111/j.2042-3306.1992.tb04773.x

Download PDF Full Text: The effects of famotidine, ranitidine and magnesium hydroxide/aluminium hydroxide on gastric fluid pH in adult horses


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Kobayashi S.; Koyama N., 1972: Effects of visible light waves on the larval growth of the silkworm bombyx mori. Journal of the Faculty of Textile Science & Technology Shinshu University Series A Biology (16): 13-18

Madan, C.; Kruger, E.; Perera, I.; Tennant, M., 2010: Trends in demand for general anaesthetic care for paediatric caries in Western Australia: geographic and socio-economic modelling of service utilisation. This study aimed to assess the temporal and spatial changes in the demand for general anaesthesia, relative to disease incidence, in 0-19-year-olds. Hospitalisation data were obtained from the Western Australian Morbidity Data System for the finan...

Sobocinski, P.Z.; Canterbury, W.J.; Knutsen, G.L.; Hauer, E.C., 1981: Effect of adrenalectomy on cadmium- and turpentine-induced hepatic synthesis of metallothionein and alpha 2-macrofetoprotein in the rat. Recent reports have strongly implicated glucocorticoids in the induction of hepatic metallothionein synthesis and hypozincemia which occurs in certain pathophysiologic conditions. Studies were performed in rats to determine the effect of adrenalec...

Reddy, G. V., 1972: Moisture use by corn (Zea mays L.) as affected by hybrid and population. In a study in 1970-1, the maize hybrids (a) U.S. 523W and (b) PAG SX29 were grown at 19 800, 39 500, 59 300 or 79 100 plants/ha to determine soil moisture use at 30-cm increments down to 150 cm. 1970 was a dry year (18 cm rain) and 1971 a normal y...

Liang, J.; Jiang, M.Jun.; Deng, X.; Xiao Zhou, X., 2013: Efficacy and Safety of Telbivudine Compared to Entecavir Among HBeAg+ Chronic Hepatitis B Patients: a Meta-Analysis Study. Hepatitis B virus (HBV) infection is a serious global health problem that is associated with huge social and economic costs. Early antiviral drugs, such as interferon-α2b, peginterferon-α2a, lamivudine, and adefovir, all have their limitations (...

Katalan Gateva Sh; Stefanov D.; Budurova L., 1979: Effect of the nematocidal preparation furadan 10 on the species composition and dynamics of soil and root nematodes in tobacco in the district of plovdiv bulgaria. Furadan was applied in 2 variants: in the form of granules introduced into the soil twice at 5 kg/decare, and once at 10 kg/decare, prior to tobacco planting. The number of nematodes [Meloidogyne incognita] in the soil dropped by 65% with double a...

Thomas, S.H.L.; Hartigan Go, K., 1996: Disposition of R - and S -terodiline in healthy man. Clinical Pharmacology & Therapeutics 59(2): 160

Albrecht, J.S.; Hirshon, J.Mark.; McCunn, M.; Bechtold, K.T.; Rao, V.; Simoni-Wastila, L.; Smith, G.S., 2015: Increased Rates of Mild Traumatic Brain Injury Among Older Adults in US Emergency Departments, 2009-2010. To estimate rates of emergency department (ED) visits for mild traumatic brain injury (TBI) among older adults. We defined possible mild TBI cases to assess underdiagnoses. Cross-sectional. National sample of ED visits in 2009-2010 captured by the...

Smith, L.R., 2016: Influencing the secretion of myogenic factors from mesenchymal stem cells. Mounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells. However, the environmental cues that affect the secreted factors o...

D.M.cco, P.; Pautrat, G.; Benkoel, L.; Pouget, M.M.; Tamalet, J., 1978: Kinetics and ultrastructure of sheep fibroblast fusion induced by polyethylene glycol. Comparison with endogenous cell fusion induced by Visna virus. The authors compare the fusion of sheep fibroblasts induced by low multiplicities of infection using visna virus and by high concentrations of polyethylene-glycol. In the case of Visna virus cell fusion is of the endogenous type, while fusion indu...