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The effects of fasting and refeeding on liver glycogen synthase and phosphorylase in obese and lean mice


, : The effects of fasting and refeeding on liver glycogen synthase and phosphorylase in obese and lean mice. Hormone and Metabolic Research 24(4): 161-166

The responses of hepatic glycogen synthase and phosphorylase to fasting and refeeding were assessed as part of an investigation into possible sites of insulin resistance in gold thioglucase (GTG) obese mice. The active forms glycogen synthase and phosphorylase (synthase I and phosphorylase a) and the total activity of these enzymes were estimated in lean and GTG mice over 48 h of food deprivation, and for 120 min after glucose average (1 g/kg wt). In lean mice there was a maximal reduction in hepatic glycogen content after 12 h of starvation and the activity of phosphorylation a decreased from 23.8 .+-. 1.9 to 6.8 .+-. 0.7 .mu.mol/g protein/min. These changes were accompanied by an increase in the activity of synthase I (from 0.14 .+-. 0.01 to 0.46 .+-. 0.04 .mu.mol/g protein/min). In obese mice, similar changes in enzyme activity occurred after 48 h of starvation. These changes were accompanied by a significant reduction in the hyperinsulinemia and hyperglycemia of the GTG mice. After glucose gavage in both lean and obese mice, the activity of synthase I further increased over the first 30 min and declined thereafter. The activity of phosphorylase a increased progressively after refeeding. Results from this study suggest that despite increased hepatic glycogen deposition, the responses of glycogen synthase and phosphorylase, in livers of obese mice, to fasting and refeeding are similar to those of control mice even in the presence of insulin resistance.

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Accession: 002249139

PMID: 1601390

DOI: 10.1055/s-2007-1003285

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Mathur, Bk; Mittal, Jp; Prasad, S., 1989: Effect of tumba cake (Citrullus colocynthis) feeding on production potential of growing heifers. Asian Australasian journal of animal sciences 2(3): 325-326

Washington, J. A. Ii ; Yu, P. K. W.; Martin, W. J., 1970: Hydrogen sulfide negative variant of citrobacter. Applied Microbiology 20(4): 587-589

Hatheway Allen W., 1996: 1994 Seattle symposium reveals complexity and value of military geology. Military geology was treated to a full-day's inspection and evaluation by 31 papers delivered at the 1994 Engineering Geology Division (EGD) Symposium at the Seattle Annual Meeting of The Geological Society of America (GSA). Even those of us...

Khomyanina N.S.; Strugatskii V.M.; Saifullina E.S., 1988: Ways of increasing the efficacy of sanatoria and health resorts in the rehabilitative treatment of gynecological patients. Sovetskoe Zdravookhranenie (8): 23-27

Vinet, E.; Lemesle, M., 1930: Essais sur les engrais appliques a la vigne. Preliminary trials with various amounts of (NH4)2SO4, KCl and K2SO4 over a 2 yr. period showed responses to both K and N the 2nd year.

Vonkennel, J., 1942: Die Wirkung und die Anwendung der Sulfanilamide. This is the 1st part of a review dealing with solubilities of various sulfonamides and their acetyl derivatives at different pH's, toxicity, antagonism by p-aminobenzoate, structural formulae, and certain clinical uses including globueid for...

Catenacci, L.S.; Griese, J.; da Silva, R.C.; Langoni, H., 2010: Toxoplasma gondii and Leishmania spp. infection in captive crab-eating foxes, Cerdocyon thous (Carnivora, Canidae) from Brazil. The zoonoses toxoplasmosis and leishmaniasis are important worldwide and also affect wild animals. Thus, the present study aimed to assess the prevalence of Leishmania spp. and Toxoplasma gondii antibodies in 52 serum samples from captive crab-eat...

Bedi, Sj; Patel, Md; Shah, Kg, 1982: Ecomorphological and phytochemical studies to determine the pollutant and its source, causing damage to vegetation: a case study of damage to banana plantation. Indian journal of ecology 9(2): 335-338

Hull M.G.R.; Bromham D.R.; Savage P.E.; Jackson J.A.M.; Jacobs H.S., 1981: Normal fertility in women with post pill amenorrhea. After exclusion of primary ovarian failure and causes of infertility not due to contraception, 48 patients with post-pill amenorrhea (PPA) and 47 patients whose amenorrhea did not follow oral contraception received treatment aimed at inducing ovul...

Nelson, V. E.; Ohrbeck, Esther; Jones, R. L.; Taylor, M. W., 1928: Cod liver oil for reproduction. Cod-liver oil (Squibb) contains not only vitamins A and D but also E. Seventh generation animals were weaned on a synthetic ration containing 5% of the oil, and reproduction was obtained on 1%. Many of the females on diets containing butter fat or...