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The effects of genetic exchange on variable antigen expression in Trypanosoma brucei


, : The effects of genetic exchange on variable antigen expression in Trypanosoma brucei. Parasitology 103 Pt 3: 379-386

The inheritance of variant surface antigens in T. brucei was determined by identifying variable antigen types (VATs) in each of 2 cloned parental stocks (STIB 247L and STIB 386AA) and then examining the presence and abundance of these VATs in hybrid progeny produced when these stocks undergo genetic exchange during co-transmission through tsetse flies.

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Accession: 002249190

PMID: 1780175

DOI: 10.1017/s0031182000059898

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Related references

Gibson, W.; Garside, L., 1991: Genetic exchange in Trypanosoma brucei brucei: variable chromosomal location of housekeeping genes in different trypanosome stocks. A Trypanosoma brucei brucei clone from West Africa was crossed with another T. b. brucei clone from the East African kiboko group. This group is defined by characteristic isoenzyme patterns and kinetoplast DNA maxicircle polymorphisms, and is asso...

Gibson, W.; Garside, L., 1991: Genetic exchange in Trypanosoma brucei brucei: variable chromosomal location of housekeeping genes in different trypanosome stocks. A Trypanosoma brucei brucei clone from West Africa was crossed with another T. b. brucei clone from the East African kiboko group. This group is defined by characteristic isoenzyme patterns and kinetoplast DNA maxicircle polymorphisms, and is asso...

Aslam, N.; Turner, C.M., 1992: The relationship of variable antigen expression and population growth rates in Trypanosoma brucei. The relationship between variable antigen type (VAT) expression and trypanosome growth rates was investigated. Growth rates in mice were compared between pairs of cloned trypanosome populations, each of which homogeneously expressed a different VA...

Borst P.; Fase Fowler F.; Gibson W.C., 1981: Quantitation of genetic differences between trypanosoma brucei gambiense trypanosoma brucei rhodesiense and trypanosoma brucei brucei by restriction enzyme analysis of kinetoplast dna. Recognition sites (44) were compared for 12 restriction endonucleases on the 20 kbase pair maxi-circle to kinetoplast DNA from 9 T. brucei stocks, 4 are infective to man (2 gambiense and 2 rhodesiense variants). In addition to 5 polymorphic sites,...

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Songa E.B.; Magnus E.; Murray M.; Van Meirvenne N., 1984: Study of the relationships between 3 variable antigen repertoires of trypanosoma brucei brucei. A comparative study of the relationships between 3 antigen repertoires of T. b. brucei revealed that 49 out of 51 cloned variable antigen types (VAT) were different. Three VAT, 1 of each repertoire, showed a high degree of cross-reactivity and, co...

Bajyana-Songa, E.V.n-Meirvenne, N.M.rray, M., 1984: Characterization of the variable antigen repetoire AnTAR 2 of Trypanosoma brucei brucei. Annales de la Societe Belge de Medecine Tropicale 64(1): 13-20

Vandenbussche G.; Cabiaux V.; Brasseur R.; Vandenbranden M.; Ruysschaert J M., 1982: Photo labeling of the variable surface antigen of trypanosoma brucei brucei. Archives Internationales de Physiologie et de Biochimie 90(2): BP19-BP20

Bajyana Songa E.; Van Meirvenne N.; Murray M., 1984: Characterization of the variable antigen repertoire antar 2 of trypanosoma brucei brucei. Antigenic variation was studied in a clone stock of T. b. brucei originating from Nigeria. Eight predominant variable antigen types were cloned and serotyped by immune lysis and immunofluorescence tests. The expression of these variants in mice an...

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