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The effects of growth hormone-releasing hormone on the secretion of islet hormones and on glucose homeostasis in lean and genetically obese-diabetic (ob/ob) mice and normal rats


, : The effects of growth hormone-releasing hormone on the secretion of islet hormones and on glucose homeostasis in lean and genetically obese-diabetic (ob/ob) mice and normal rats. Journal of Endocrinology 123(1): 19-24

Synthetic human growth hormone-releasing hormone(1-40) (hGHRH-40) was studied in normal lean and genetically obese-diabetic (ob/ob) mice and adult male Wistar rats. Islets of Langerhans were prepared by collagenase digestion. Results showed that the addition of hGHRH-40 1 micro mol/litre to incubated islets from normal lean mice increased insulin release by 90 and 37% at glucose 5.6 and 16.7 mmol/litre, respectively.

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