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The effects of host diet on Plasmodium yoelii nigeriensis

, : The effects of host diet on Plasmodium yoelii nigeriensis. Journal of Parasitology 76(6): 903-912

A comparative study carried out on infected mice to investigate the effect of host diet on Plasmodium yoelii nigeriensis showed that concentrations of blood protein, hemoglobin, and erythrocytes began to decrease in infected mice on day 2 after inoculation and reached the lowest levels on day 8. The greatest decrease was among mice fed on protein-rich mouse cubes, whereas the least decrease was among mice fed on cassava meal. Inflammation of the spleens and livers of infected mice also was noticed. Leucocyte numbers and parasitemia in infected mice reached their peaks on day 8. Again, the greatest prevalence of these abnormalities was apparent among mice whose diet contained the highest amount of protein in comparison to the other diets used in this study. The abnormalities decreased proportionately among the other groups of infected mice, corresponding to the protein content of their various diets. Mice fed on cassava meal, with the lowest content of protein, had the fewest abnormalities. Elevated body temperature, characteristic of severe malaria, and extensive liver damage were highest among mice with the greatest amount of protein in their diet. In view of these observations, it was surmised that during malaria, host diets high in protein heighten the severity of this disease.

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Accession: 002249223

PMID: 2254825

DOI: 10.2307/3282812

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Related references

Ibekwe C.A.C.; Ugwunna S.C., 1990: The effect of host diet on plasmodium yoelii nigeriensis. A comparative study carried out on infected mice to investigate the effect of host diet on Plasmodium yoelii nigeriensis showed that concentrations of blood protein, hemoglobin, and erythrocytes began to decrease in infected mice on day 2 after in...

Fagbenro-Beyioku, A.F.; Oyerinde, J.P., 1990: Effect of host-diet inadequacy on the course of infection of plasmodium yoelii Nigeriensis. Investigations were conducted into the course of infection of plasmodium yoelli nigeriensis in mice fed on an inadequate diet. It was found that mice fed on a '1/2' diet were able to withstand infection with the parasite better than mice...

Taylor, P.J.; Hurd, H., 1996: Effects of changes in host packed-cell volumes induced by Plasmodium yoelii nigeriensis on the feeding behaviour and bloodmeal size of Anopheles gambiae. Annals of Tropical Medicine & Parasitology 90(4): 424-425

Krugliak, M.; Deharo, E.; Shalmiev, G.; Sauvain, M.; Moretti, C.; Ginsburg, H., 1995: Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. The effects of the C18 fatty acids oleic, elaidic, linoleic and linolenic on malaria parasites were investigated. These fatty acids inhibited parasitaemia in mice infected with Plasmodium vinckei petteri or P. yoelii nigeriensis in a 4-day suppres...

Sawyer, B.; Guy, MW.; Davidson, G.; White, GB., 1982: Effects of coumarin on sporogony of Plasmodium yoelii nigeriensis. Mosquito Studies at the London School of Hygiene and Tropical Medicine Progress Report, 26 No. 43

Prasittisuk, C.; Curtis, C.F., 1982: Absence of effects of insecticides on susceptibility of anophelines to Plasmodium yoelii nigeriensis. Susceptibility of genetically susceptible strains of Anopheles gambiae or A. stephensi to infection by Plasmodium yoelii nigeriensis was unaffected by insecticides

Sinden R.E.; Hartley R.H.; King N.J., 1985: Gametogenesis in plasmodium yoelii nigeriensis the inhibitory effects of anticytoskeletal agents. Gametocytes of P. yoelii were incubated with colchicine, vinblastine sulfate and cytochalasin B and then induced to undergo gametogenesis. All the drugs inhibited gamete formation in a dose and time dependent manner. EM revealed that colchicine an...

Franco, A.S.; Silveira, H.; do Rosário, Vílio.E., 2003: Plasmodium yoelii: semiquantitative analyses of circumsporozoite protein gene expression during the sporogonic development of P. y. yoelii and P. y. nigeriensis in the mosquito vector Anopheles stephensi. Malaria infection in the mosquito vector can be modulated by the vertebrate host, mosquito factors, and interactions between different parasite populations. Modulation of parasite development can be assessed through the study of gene expression. T...

Kurihara, T.; Kikuchi, T., 1991: Effects of oocyst number of Plasmodium yoelii nigeriensis on activities of infected mosquitoes. In an experiment where hungry females of Anopheles sinensis, which had fed on mice infected with P. yoelii nigeriensis 10 days earlier, were able to pass through a wide-mesh net to a bait mouse, the rate of entering the bait cage was highest in mo...

Carwardine, S.L.; Hurd, H., 1997: Effects of Plasmodium yoelii nigeriensis infection on Anopheles stephensi egg development and resorption. It has been shown previously that infection with Plasmodium yoelii nigeriensis reduces the number of eggs produced by female Anopheles stephensi. Here we examine the mechanism underlying fecundity reduction. Ovaries from infected and uninfected (c...