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The effects of low levels of dietary toxic weed seeds (jimson weed, Datura stramonium and sicklepod, Cassia obtusifolia) on the relative size of rat liver and levels and function of cytochrome P-450


, : The effects of low levels of dietary toxic weed seeds (jimson weed, Datura stramonium and sicklepod, Cassia obtusifolia) on the relative size of rat liver and levels and function of cytochrome P-450. Toxicology Letters 54(2-3): 175-181

Preliminary studies and previous work by other investigators have shown that jimsonweed and sicklepod seeds are very toxic. Such seeds and others are co-harvested and are often found mingling with commercial grain destined for human consumption. Low levels of these seeds were studied here to determine whether such levels would show signs of intoxication in rats by modulating growth, liver weight and relative size, cytochrome P-450 levels and function, and other relevant parameters proven to be sensitive to low levels of toxicants. Assessment of these factors showed that jimson weed does give indications of intoxication at low levels, whereas the highly toxic sicklepod does not give discernible indications.

Accession: 002249289

PMID: 2260115

DOI: 10.1016/0378-4274(90)90181-K

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Related references

Crawford, L.; Friedman, M., 1990: The effects of low levels of dietary toxic weed seeds (jimson weed, Datura stramonium and sicklepod, Cassia obtusifolia) on the relative size of rat liver and levels and function of cytochrome P-450. Preliminary studies and previous work by other investigators have shown that jimsonweed and sicklepod seeds are very toxic. Such seeds and others are co-harvested and are often found mingling with commercial grain destined for human consumption. L...

Friedman M.; Henika P.R., 1991: Mutagenicity of toxic weed seeds in the ames test jimson weed datura stramonium velvetleaf abutilon theophrasti morning glory ipomoea spp and sicklepod cassia obtusifolia. Commercial grains, such as soybean and wheat, may be contaminated with nongrain impurities such as toxic weed seeds that coexist with harvested crops. The present study investigated the genotoxic potential of seeds from four nongrain sources: jims...

Crawford, L.; McDonald, G.M.; Friedman, M., 1990: Composition of sicklepod (Cassia obtusifolia) toxic weed seeds. Journal of Agricultural and Food Chemistry 38(12): 2169-2175

Friedman M.; Levin C.E., 1989: Composition of jimson weed datura stramonium seeds. Bulk commercial grain, such as soybeans and wheat, may be contaminated by nongrain impurities, including jimson weed seeds, that coexist with the crop to be harvested. The present study was undertaken to determine the content of the major alkaloid...

Horejsi, V.; Kocourek, J., 1978: Studies on lectins part 37 isolation and characterization of the lectin from jimson weed seeds datura stramonium. The lectin of Jimson-weed seeds (D. stramonium L.) was isolated by affinity chromatography on a polysaccharide mixture from mycelium of Aspergillus niger. The lectin yields 2 bands on disc electrophoresis, it has sedimentation coefficient s20,w =...

Horejsí, V.; Kocourek, J., 1978: Studies on lectins. XXXVII. Isolation and characterization of the lectin from Jimson-weed seeds (Datura stramonium L.). The lectin of Jimson-weed seeds (Datura stramonium L.) was isolated by affinity chromatography on a polysaccharide mixture from mycelium of Aspergillus niger. The lectin yields two bands on disc electrophoresis, it has sedimentation coefficient s2...

Horejsi, V.K.courek, J., 1978: Studies on lectins. XXXVII. Isolation and characterization of the lectin from Jimson weed seeds (Datura stramonium L.). Biochimica et biophysica acta: 532 (1) 92-97

Friedman, M., 2004: Analysis of biologically active compounds in potatoes (Solanum tuberosum), tomatoes (Lycopersicon esculentum), and jimson weed (Datura stramonium) seeds. Potatoes and tomatoes, members of the Solanaceae plant family, serve as major, inexpensive low-fat food sources providing for energy, high-quality protein, fiber, vitamins, pigments, as well as other nutrients. These crops also produce biologicall...

Friedman, M., 2004: Analysis of biologically active compounds in potatoes (Solanum tuberosum), tomatoes (Lycopersicon esculentum), and jimson weed (Datura stramonium) seeds. Potatoes and tomatoes, members of the Solanaceae plant family, serve as major, inexpensive low-fat food sources providing for energy, high-quality protein, fiber, vitamins, pigments, as well as other nutrients. These crops also produce biologicall...

Blakeslee, A.F.; Belling, J.; Farnham, M.E.; Bergner, A.D., 1922: A HAPLOID MUTANT IN THE JIMSON WEED, "DATURA STRAMONIUM". Science 55(1433): 646-647