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The effects of uremia and dietary phosphorus on the bone of rats


, : The effects of uremia and dietary phosphorus on the bone of rats. Bone (New York) 11(1): 41-46

In order to evaluate the effects fo uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 .+-. 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0.3%) (NCNP), or normal calcium and low phosphorus (0.03%). When compared to the NCNP SO group after seven days, only uremic rats fed low phosphorus diets developed osteomalacia characterized by an increase in the osteoid thickness, surface and volume, a prolonged osteoid maturation time, and a decreased bone formation rate. No other groups developed these changes. This osteomalacia was also associated with hypophosphatemia, a reduced serum PTH and an elevation in the serum 1,25(OH)2D3. It was concluded that while neither this degree of uremia nor the low phosphorus diets alone had any significant effect, the combination of uremia and low dietary phosphorus resulted in the initiation of osteomalacia. This animal model should prove useful in investigations dealing with the influence of uremia on the mineralization process.

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Accession: 002249623

PMID: 2331430

DOI: 10.1016/8756-3282(90)90070-F

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Nawar, M.M.; Hamza, H.A., 1978: Influence of maleic hydrazide mixed with ethyl methanesulfonate on mutation frequencies induced in drosophila melanogaster. Postmeiotic germ cells of D. melanogaster treated with saturated aqueous solutions of maleic hydrazide failed to show significant increases in frequencies of either dominant or recessive sex linked lethals. Treatment of similar cells with mixtures...

Araki, J., 1967: Necessary precautions in swimming. Nursing Technique 19(7): 107-110

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Robinson S., 1969: Immediate and delayed effects of acute dehydration on plasma volume in man. Physiologist: 310

MORRIS, E.W., 1965: Embryology Of Some Congenital Cardiac Anomalies. Thorax 20: 158-169

Hemmeloff Andersen K.E., 1980: Serum enzyme levels during initial peritoneal dialysis. Serum creatine kinase (CK), aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and lactic dehydrogenase (LDH) levels were studied at initial peritoneal dialysis in 2 groups of patients with renal failure. In group I the patients un...