EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The efficacy of itraconazole against systemic fungal infections in neutropenic patients: a randomised comparative study with amphotericin B


, : The efficacy of itraconazole against systemic fungal infections in neutropenic patients: a randomised comparative study with amphotericin B. Journal of Infection 22(1): 45-52

In a randomized clinical trial, the efficacy of itraconazole (200 mg orally twice daily) was compared with that of amphotericin B (Fungizone) (0.6 mg/kg daily or 0.3 mg/kg in combination with flucytosine (Ancotil)) in neutropenic (<500 x 106/litre neutrophils) patients with proven or highly suspected systemic fungal infections (15 Candida albicans, 1 Candida, 7 Aspergillus fumigatus, 1 A. niger, 1 A. flavus, 4 Aspergillus and 3 unidentified). Patients with unexplained fever alone were not included in the study. Of the 40 patients enrolled, 32 patients (16 males, 16 females) were evaluable. Sixteen patients (median age 51 yrs) were treated with itraconazole for a median period of 20 d and 16 patients (median age 32 yrs) received amphotericin B for a median period of 13 d. The overall clinical response was 10 of 16 (63%) for patients treated with itraconazole and 9 of 16 (56%) for patients treated with amphotericin B (P>0.90). Itraconazole seemed to be more effective against Aspergillus infections, whereas amphotericin B seemed to be more effective against candidal infections, although the differences were not statistically significant.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002249703

DOI: 10.1016/0163-4453(91)90954-q

PDF Full Text: The efficacy of itraconazole against systemic fungal infections in neutropenic patients: a randomised comparative study with amphotericin B


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Beckwith, L.; Crawford, S.; Moore, J.A.; Howard, J., 1995: Attentional and social functioning of preschool-age children exposed to PCP and cocaine in utero. Lewis, M [Editor], Bendersky, M [Editor] Mothers, babies, and cocaine: The role of toxins in development 287-303

Hemming,S.; Rigney,D., 2010: Decentring the new protectors transforming Aboriginal heritage in South Australia. Disciplines such as archaeology, anthropology and history exercise a seemingly disproportionate influence on race relations in settler democracies. In South Australia, this influence has complex and unbroken genealogies linked to the beginnings of...

Eggena P.; Fahrenholz F.; Schwartz I.L., 1983: Irreversible stimulation of hydro osmotic response in toad bufo marinus bladder by photo affinity labeling with 2 l phenylalanine p azidophenylalanine vasopressin. The photoreactive analogs of vasopressin, [Phe2,Phe-(p-N3)3]AVP (3a) and [Phe-(p-N3)2]AVP (2a), and the chemically reactive analogs of vasopressin, [Phe2,Phe-(p-NHCOCH2Br)3]AVP (3b) and [Phe-(p-NHCOCH2Br)2]AVP (2c), were tested in the toad bladder...

Ito, Y.; Mural, M.; Teruya, T.; Hamada, R.; Sugimoto, A., 1974: An estimation of population density of Dacus cucurhitae with mark-recapture methods. Researches Popul Ecol Kyoto Univ, 152: 213-222

LOI.L.; FERRARI.E., 1950: Pickworth method applied to the study of renal circulation in shock; experimental research. Archivio Italiano di Urologia 24(3): 172-179

Krahenbuhl, G.S.; Pangrazi, R.P., 1983: Characteristics associated with running performance in young boys. The purpose of the study was to replicate and extend the investigation of characteristics associated with running performance in young boys. Two groups of 10-year-old males were studied. One group (A runners) consisted of subjects who placed above...

Kmetzsch, C.I.; Balkie, E.M.R.; Monteiro, A.; Costa, E.V.; dos Santos, G.P.L.; da Silva, E.E., 2006: Echovirus 13 aseptic meningitis, Brazil. Emerging Infectious Diseases 12(8): 1289-1290

Lichtenstein, E.Paul; Liang, T.T.; Koeppe, M.K., 1983: Effects of soil mixing and flooding on the fate and metabolism of 14C-fonofos and 14C-parathion in open and closed agricultural microcosms. Journal of Economic Entomology 76: 3-8

Pedralli, G., 1978: New occurrences of lauraceae in the brazilian state of rio grande do sul. Species [3] not yet mentioned in the botanical literature of Rio Grande do Sul, Brazil are described. They are Cinnamomum glaziovii (Mez) Vatt., Phoebe stenophylla (Meissn.) Mez and P. sellowiana (Nees) Meissn. ex Mez.

Markus H.; Ruvolo A., 1989: Possible selves personalized representations of goals. Pervin, L A (Ed ) Goal Concepts in Personality And Social Psychology Viii+509p Lawrence Erlbaum Associates, Inc , Publishers: Hillsdale, New Jersey, Usa; London, England, Uk Illus Maps 211-242