EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The embryogenesis of Onchocerca volvulus over the first year after a single dose of ivermectin


Tropical Medicine and Parasitology 42(3): 175-180
The embryogenesis of Onchocerca volvulus over the first year after a single dose of ivermectin
Adult Onchocerca volvulus, extracted from nodules before, and at intervals of two weeks to 12 months after, a single 150 .mu.g/kg dose of ivermectin, were examined longitudinally and by sequential transverse sections. The mean number of male worms per nodule fell, and the proportion of nodules with no worms per nodule fell, and the proportion of nodules with no male worm rose, within two weeks of ivermectin and remained so for 12 months. In female worms, at intervals after ivermectin, the percentages of the length of the lower genital tracts occupied by embryos at each stage of development, or by degenerating ova, embryos and microfilariae (mfs), were recorded: (a) in un(re-)inseminated worms whose original embryogenesis was continuing and in those in which it was completed; and (b) in worms, reinseminated post-ivermectin, in which a new embryogenesis had begun. The results indicated that: (a) the time needed for the zygotes of O. volvulus to develop to mfs is 8-12 weeks; (b) nearly 40 percent of females had not resumed mf production by 12 months after treatment; (c) many intrauterine mfs had not degenerated within the first two weeks of ivermectin; (d) some of the last embryos to mature to mfs did not degenerate but accumulated temporarily in the anterior uteri 8-16 weeks after ivermectin.


Accession: 002249820

PMID: 1801140



Related references

The embryogenesis of onchocerca volvulus over the first year after a single dose of invermectin. Tropical Medicine & Parasitology 42(3): 175-180, 1991

Effect of single dose ivermectin on Onchocerca volvulus: A systematic review. 2007

Ivermectin effect on microfilariae of Onchocerca volvulus after a single oral dose in humans. Tropical Medicine and Parasitology 38(1): 8-10, 1987

A controlled prospective trial of the prophylactic effect of a single dose of ivermectin against Onchocerca volvulus. Parasite 8(3): 255-259, 2001

Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis. Lancet. Infectious Diseases 8(5): 310-322, 2008

Comparison of the effects of a single dose and of four six-monthly doses of ivermectin on adult Onchocerca volvulus. American Journal of Tropical Medicine and Hygiene 45(1): 132-137, 1991

Effect of single-dose ivermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement. British Journal of Ophthalmology 72(8): 561-569, 1988

A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. Plos Neglected Tropical Diseases 8(6): E2953-E2953, 2016

Transmission of Onchocerca volvulus continues in Nyagak-Bondo focus of northwestern Uganda after 18 years of a single dose of annual treatment with ivermectin. American Journal of Tropical Medicine and Hygiene 89(2): 293-300, 2013

The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients. Transactions of the Royal Society of Tropical Medicine and Hygiene 93(2): 189-194, 1999