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The eosinophil in parasitic infections


, : The eosinophil in parasitic infections. Current Concepts in Parasitology: 7-46

This chapter discusses the role of the eosinophil in parasitic infections in 8 main sections: introduction; the biology of eosinophils (production and distribution, morphology and constituents of eosinophils, granule associated proteins, granule-associated enzymes, membrane receptors); the mechanism of eosinophilia (medullary eosinophilia, local eosinophilia, T cell-independent eosinophilia, genetic differences in eosinophil responses); parasite killing by eosinophils in vitro (IgG antibody-dependent killing, IgE antibody-dependent killing, complement-dependent killing), and in vivo (killing mechanisms, cationic proteins, eosinophil peroxidase and active oxygen products, and phospholipase A); activation and inhibition of eosinophil functions. The last 3 sections are short sections on: recent findings, future perspectives and a summary.

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