EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The epitope of a protective monoclonal antibody occurs in a region of microheterogeneity in Plasmodium chabaudi






Molecular and Biochemical Parasitology 42(1): 153-154

The epitope of a protective monoclonal antibody occurs in a region of microheterogeneity in Plasmodium chabaudi

The nucleotide sequence of the homologous region of the MSA1 (major merozoite surface antigen precursor) genes from P. chabaudi adami DK and P. chabaudi chabaudi CB is reported and compared with that in P. chabaudi adami DS. The alignment of the predicted protein sequence of this segment is given. There is a single nucleotide difference between DS and DK. The amino acid homology between DS and DK, CB, P. yoelii YM and P. falciparum Fc27 is 99.8, 77, 53 and 25% respectively. The single amino acid change between DS and DK (Thr to Ile) resides in the core epitope region of the protective monoclonal antibody 5C10/66. This is compared to a similar region of microheterogeneity between P. falciparum Fc27 and P. falciparum Camp. It is suggested that regions of microheterogeneity are selected for to evade protective immune responses.

Accession: 002249995

PMID: 1700297

DOI: 10.1016/0166-6851(90)90123-4

Download PDF Full Text: The epitope of a protective monoclonal antibody occurs in a region of microheterogeneity in Plasmodium chabaudi



Related references

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami. Proceedings of the National Academy of Sciences of the United States of America 86(10): 3768-3772, 1989

A second region recognized by the protective monoclonal antibody 5C10/66 in the precursor to the major merozoite surface antigen of Plasmodium chabaudi adami. Molecular and Biochemical Parasitology 41.2: 289-292, 1990

In vivo selection of populations of Plasmodium chabaudi chabaudi AS resistant to a monoclonal antibody that reacts with the precursor to the major merozoite surface antigen. Infection and Immunity 57(7): 2128-2135, 1989

Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody. American Journal of Tropical Medicine and Hygiene 47(6): 837-843, 1992

A monoclonal antibody raised against Plasmodium chabaudi chabaudi soluble antigens present in the serum of infected mice recognizes a 250 kDa schizont glycoprotein that is secreted during schizogony. Memorias do Instituto Oswaldo Cruz 92(SUPPL 1): 258, 1997

Plasmodium chabaudi chabaudi: a monoclonal antibody raised against soluble antigens present in the plasma of infected mice recognizes a 250-kDa schizont glycoprotein that is secreted during schizogony. Experimental Parasitology 91(1): 97-100, 1999

The 3' portion of the gene for a Plasmodium yoelii merozoite surface antigen encodes the epitope recognized by a protective monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America 85(2): 602-606, 1988

Protective immunity to malaria. Studies with cloned lines of Plasmodium chabaudi chabaudi and Plasmodium berghei in CBA. Parasite immunology 8(3): 239-254, 1986

Protective immunity to malaria: studies with cloned lines of Plasmodium chabaudi chabaudi in CBA/Ca mice. III. Protective and suppressive responses induced by immunization with purified antigens. Parasite Immunology 10(1): 1-15, 1988

A protective monoclonal antibody recognizes a variant-specific epitope in the precursor of the major merozoite surface antigen of the rodent malarial parasite Plasmodium yoelii. Journal of Immunology 142(8): 2835-2840, 1989