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Yeast artificial chromosomes (YACs) and the analysis of complex genomes



Yeast artificial chromosomes (YACs) and the analysis of complex genomes



Trends in Biotechnology 10(1-2): 35-40



The development of yeast artificial chromosome (YAC) cloning vectors capable of carrying several hundred kilobase-pairs of DNA insert has greatly facilitated the study of complex genomes, and the cloning of large genes as single fragments. In addition, the ability to manipulate YAC sequences by homologous recombination makes this system extremely useful for the generation of disease models.

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Accession: 002279440

Download citation: RISBibTeXText

PMID: 1367930

DOI: 10.1016/0167-7799(92)90165-r


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