A DNA polymorphism for lecithin:cholesterol acyltransferase (LCAT) is associated with high density lipoprotein cholesterol concentrations in baboons

Kammerer, C.M.; Hixson, J.E.; Mott, G.E.

Atherosclerosis 98(2): 153-163


ISSN/ISBN: 0021-9150
PMID: 8457258
DOI: 10.1016/0021-9150(93)90125-e
Accession: 002281464

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The effects of a polymorphic PvuII site in the gene for lecithin:cholesterol acyltransferase (LCAT) on serum HDL cholesterol (HDL-C) and apolipoprotein A-I (apo A-I) values in a population of 750 pedigreed baboons were investigated. Tests were conducted for genotype by diet interactions using data on HDL-C and apo A-I values on 2 diets (standard and high-cholesterol, saturated fat). A significant (P<0.001) association between the LCAT genotypes and HDL-C values was observed. On both diets, baboons homozygous for the less common allele had HDL-C values that averaged 18-19% lower than baboons homozygous for the more common allele. HDL-C values of the heterozygotes were intermediate. The LCAT restriction fragment length polymorphism accounted for about 5% of the variation in HDL-C values on the 2 diets. No strong evidence for an LCAT genotype/diet interaction was observed.