EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections






Infection and Immunity 61(1): 40-47

A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections

The human humoral immune response to the Plasmodium falciparum merozoite surface antigen gp190 was analyzed to determine the rate of reinfection by the parasite and the ability to control parasite density. The prospective study was carried out in a West African village where malaria is hyperendemic. No correlation between the antibody titers and protection against infection was observed within the group of children. Positive and negative associations of antibody specificities with protection against and/or control of parasitemia were, however, found for adolescents and adults, respectively. Thus, in adolescents, the presence of antibodies to gp190 fragment M6 correlates with a 50% reduced risk of P. falciparum infection and in increased ability to control parasitemia, whereas in adults, the humoral response to some of the polymorphic regions of gp190 associates with an increased risk of infection.

(PDF 0-2 workdays service: $29.90)

Accession: 002287497

PMID: 8418064



Related references

The host immune responses to Plasmodium falciparum: Part II--T-cell regulation of human immune responses to Pf155/RESA, a well-defined blood-stage antigen of Plasmodium falciparum: a review. Indian Journal of Malariology 31(1): 12-20, 1994

Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum. Infection and Immunity 57(12): 3765-3769, 1989

The structure of some antigens of the asexual blood stage of plasmodium falciparum related to the humoral immune response. Journal of Cellular Biochemistry Supplement (10 PART A): 150, 1986

Expression of a cDNA clone that recognizes an asexual blood stage antigen from the human malarial parasite Plasmodium falciparum. Biotecnologia Aplicada 9(2): 130-139, 1992

Humoral and cellular immune responses to synthetic peptides from the Plasmodium falciparum blood-stage antigen, Pf155/RESA, in Cameroonian women. Clinical Immunology and Immunopathology 76(2): 164-169, 1995

Humoral immune responses elicited against a multiple antigen peptide containing an epitope from Plasmodium falciparum liver stage antigen-1. Immunology 98(suppl 1): 130, 1999

Cellular and humoral immune responses to well-defined blood stage antigens (major merozoite surface antigen) of Plasmodium falciparum in adults from an Indian zone where malaria is endemic. Infection and Immunity 62(2): 685-691, 1994

An epidemiological study of humoral and cell-mediated immune response to the Plasmodium falciparum antigen PF155/RESA in adult Liberians. American Journal of Tropical Medicine and Hygiene 41(4): 386-394, 1989

Characterization of the humoral immune response in plasmodium falciparum malaria 1. estimation of antibodies to plasmodium falciparum or human erythrocytes by means of micro elisa enzyme linked immuno sorbent assay. Clinical and Experimental Immunology 54(1): 127-134, 1983

Characterization of the humoral immune response in Plasmodium falciparum malaria. I. Estimation of antibodies to P. falciparum or human erythrocytes by means of microELISA. Clinical and Experimental Immunology 54(1): 127-134, 1983