Section 3
Chapter 2,290

A subfraction, derived from a non-protective extract of Leishmania infantum, protects BALB/c mice against L. major infection

Rolland, L.; Sally, V.; Vijayalakshmi, M.

Comptes Rendus de l' Academie des Sciences Serie III, Sciences de la Vie 316(11): 1342-1349


ISSN/ISBN: 0764-4469
Accession: 002289923

The preparation of a Leishmania infantum extract and its further separation by gel filtration liquid chromatography are described. An extract (S) prepared from stationary promastigotes of a strain of L. infantum, uninfective to BALB/c mice, in conjunction with BCG as adjuvant did not protect mice against challenge with a virulent strain of L. major. Chromatographic separation of S yielded 5 fractions, designated P0 to P4.

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