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Angiotensin II receptor antagonist markedly reduces mortality in salt-loaded Dahl S rats



Angiotensin II receptor antagonist markedly reduces mortality in salt-loaded Dahl S rats



American Journal of Hypertension 4(4 Pt 2): 346s-349s



The effect of blockade of the renin-angiotensin system on morbidity and hypertension was studied in 198 Dahl salt-sensitive (Dahl S) rats 6 weeks old given a diet high in sodium (8% NaCl) for 10 weeks. One group of 91 was treated with the non-peptide angiotensin II receptor antagonist, DuP 753, 30 mg/kg daily whereas 107 controls were untreated. Blood pressure increased steeply in both groups, and was above 200 mm Hg by week 6.

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Accession: 002301426

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PMID: 1854463



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