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Animal model of human disease. Pulmonary cryptococcosis



Animal model of human disease. Pulmonary cryptococcosis



American Journal of Pathology 141(6): 1517-1520



A disease model of Cryptococcus neoformans infection is described in mice. Intratracheal inoculation of BALB/c or CB-17 mice with C. neoformans 52D resulted in pulmonary infection that resolved after the development of T-cell-mediated immunity. By manipulating the immune response of infected mice by T-cell depletion at different points during infection, pathogenesis of the pulmonary disease in immunocompetent mice was studied.

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Accession: 002301529

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