+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Baked rye products modify cholesterol metabolism and crypt cell proliferation rates in rats

Journal of Nutrition 123(11): 1834-1843
Baked rye products modify cholesterol metabolism and crypt cell proliferation rates in rats
Young adult male rats were made hypercholesterolemic by feeding cholesterol (+ cholic acid). The effect of rye crispbread on hepatic and plasma cholesterol concentrations, hepatic cholesterol synthesis, small intestinal cell turnover and fecal output was investigated. Diets containing 50 and 75% rye crispbread (g dry wt) were compared with positive control diets of similar gross composition, in which the insoluble component of rye was matched with cellulose and the soluble component with guar gum. A negative control diet containing no non-starch polysaccharide was also included. Cholesterol supplementation was maintained in half the rats on each diet. Rye caused a marked increase in fecal output that was greater than that seen in the positive control groups. However, crypt cell proliferation in the small intestine was less than that seen in the high fiber control groups. Rye reduced total plasma cholesterol concentrations only in those rats that continued to receive the high cholesterol diet. However, whether or not cholesterol was fed, the presence of non-starch polysaccharide caused a decrease in liver cholesterol concentrations. Rye caused a marked increase in hepatic cholesterol synthesis over both the positive controls and the rats fed a fiber-free diet. This implies that rye causes a loss of cholesterol from the body, probably due to malabsorption of bile acids and cholesterol.

Accession: 002308060

PMID: 8229298

Related references

Cholesterol metabolism and crypt cell proliferation rates in response to rye based diets. Proceedings of the Nutrition Society 52(3): 373A, 1993

Small intestinal crypt cell proliferation rates are increased in senescent rats. Journal of Gerontology 44(1): B9-14, 1989

Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently. American Journal of Pathology 151(3): 843-852, 1997

Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. Nutrition and Cancer 43(2): 193-201, 2003

Effect of dietary deoxycholic acid and cholesterol on fecal steroid concentration and its impact on the colonic crypt cell proliferation in azoxymethane-treated rats. Cancer Letters. 124(1): 79-84,. 13, 1998

Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats. Journal of Toxicology and Environmental Health. Part A 62(7): 561-573, 2001

Gastrointestinal responses to oats consumption in young adult and elderly rats: digestion, large bowel fermentation and crypt cell proliferation rates. British Journal of Nutrition 70(2): 567-584, 1993

Studies on the effect of marine products on cholesterol metabolism in rats 7. The influence of dried purple laver on cholesterol levels of organs and cholesterol excretion in rats. 1967

Fructo-oligosaccharides and iron bioavailability in anaemic rats: the effects on iron species distribution, ferroportin-1 expression, crypt bifurcation and crypt cell proliferation in the caecum. British Journal of Nutrition 112(8): 1286-1295, 2014

Does increased crypt cell proliferation impair cholesterol absorption after proximal gut resection?. Scandinavian Journal of Gastroenterology 35(7): 719-725, 2000