EurekaMag.com logo
+ Translate

Behavioral and biochemical effects of postnatal parathion exposure in the rat


, : Behavioral and biochemical effects of postnatal parathion exposure in the rat. Neurotoxicology & Teratology 10(3): 261-266

Preweanling rat pups were exposed daily to parathion (1.3 mg/kg or 1.9 mg/kg) or vehicle (corn oil) on postnatal days 5-20, a time period critical to development of behavioral and biochemical parameters of the cholinergic nervous system. The exposure resulted in dose-dependent reduction in acetylcholinesterase activity and muscarinic receptor binding in the cortex. During the preweanling period, there were no differences among the groups in most reflex measures, eye opening or incisor eruption. Postweanling behavioral assessment revealed small deficits in tests of spatial memory in both the T-maze and the radial arm maze. There were no differences in neuromuscular abilities or spontaneous activity measures. Thus, biochemical and behavioral deficits in cholinergic nervous system functioning occurred in the absence of severe signs of toxicity and in the absence of generalized nonspecific behavioral disturbances.

Accession: 002308822

PMID: 3211105

DOI: 10.1016/0892-0362(88)90026-8

Download PDF Full Text: Behavioral and biochemical effects of postnatal parathion exposure in the rat


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Stamper, C.; Balduini, W.M.rphy, S.; Costa, L., 1987: Behavioral and biochemical effects of early postnatal parathion exposure in the rat. NATO ASI series: Series H: Cell biology3(13): 305-309

Crowder, L.A.; Lanzaro, G.C.; Whitson, R.S., 1980: Behavioral effects of methyl parathion and toxaphene exposure in rats. The behavior of rats exposed peri- and postnatally to methyl parathion (MP) and toxaphene (T) [insecticides] was examined with a variety of maturational and learning tests. Females received daily oral doses of 1.0 mg/kg MP or 1.0 mg/kg MP + 2.0 mg...

Castillo, C.G.; Montante, M.; Dufour, L.; Martinez, M.L.; Jimenez Capdeville, M.E., 2002: Behavioral effects of exposure to endosulfan and methyl parathion in adult rats. Endosulfan (ES) and methyl parathion (MP) are widely used in Latin America, and simultaneous exposure to both products is documented. This exposure may have effects on the nervous system because their targets include the GABAergic and cholinergic...

Gáspár, E.; Heeringa, M.; Markel, E.; Luiten, P.G.; Nyakas, C., 1992: Behavioral and biochemical effects of early postnatal cholinergic lesion in the hippocampus. The effects of early postnatal (PD 8) intracerebroventricular injection of ethylcholine mustard aziridinium ion (AF64A) on development of open-field and cognitive behaviors and cholinergic markers in several brain areas were examined in the rat. T...

Gramatte T.; Wustmann C.; Schmidt J.; Fischer H D., 1986: Effects of nootropic drugs on some behavioral and biochemical changes after early postnatal hypoxia in the rat. Piracetam (PIR) and dimethylaminoethanol (DMAE) were tested with respect to their ability to prevent changes of the locomotor behaviour and of the dopamine release from striatum slices after an intermittent postnatal hypoxia in the rat (2nd-10th d...

Gaspar E.; Heeringa M.; Markel E.; Luiten P.G.M.; Nyakas C., 1992: Behavioral and biochemical effects of early postnatal cholinergic lesions in the hippocampus. The effects of early postnatal (PD 8) intracerebroventricular injection of ethylcholine mustard aziridinium ion (AF64A) on development of open-field and cognitive behaviors and cholinergic markers in several brain areas were examined in the rat. T...

Geist, C.R.; Balko, S.W.; Morgan, M.E.; Angiak, R., 1985: Behavioral effects following rehabilitation from postnatal exposure to lead acetate. At 21 days of age three groups of male hooded rats of the Sprague-Dawley strain were exposed to either untreated water or lead acetate at concentrations of 25 or 50 ppm provided ad lib. in the drinking water for 40 days. When tested for spontaneou...

Hughes, J.A.; Annau, Z., 1976: Postnatal behavioral effects in mice after prenatal exposure to methylmercury. CFW mice were injected with methylmercury hydroxide (1, 2, 3, 5 or 10 mg/kg as mercury) on Day 8 of gestation. Mice treated with 3, 5 or 10 mg/kg averaged 1/3 fewer pups than controls. Pups from these treated animals weighed less than controls and...

Palermo-Neto, J.; Sákaté, M.; Flório, J.C., 1997: Developmental and behavioral effects of postnatal amitraz exposure in rats. The effects of postnatal amitraz exposure on physical and behavioral parameters were studied in Wistar rats, whose lactating dams received the pesticide (10 mg/kg) orally on days 1, 4, 7, 10, 13, 16 and 19 of lactation; control dams received disti...

Olson, K.; Boush, G.; Matsumura, F., 1980: Pre and postnatal exposure to dieldrin: persistent stimulatory and behavioral effects. Dieldrin was fed to two generations of albino rats at levels often found in the environment (0.35 g/kg/day, orally). A two-by-two factorial design was employed to investigate the simultaneous effect of a malnutrition condition consisting of low pr...