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Borna disease virus: molecular analysis of a neurotropic infectious agent

, : Borna disease virus: molecular analysis of a neurotropic infectious agent. Microbial Pathogenesis 13(3): 167-170

Though infectious material has not been isolated from man, antibodies reactive with Borna disease virus (BDV) specific proteins have been identified in patients with bipolar depression, schizophrenia and AIDS-encephalopathy.

Accession: 002313006

PMID: 1291839

DOI: 10.1016/0882-4010(92)90017-I

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Related references

Lundgren, A.L.; Berg, M., 1997: Borna disease virus: an emerging neurotropic agent?. Following a review of the historical background, epidemiology, and clinical manifestations of Borna disease virus (BDV) infection in various animal species, an account of the first occurrence of the disease in Swedish horses is described. Of the 7...

Richt, J.A.; VandeWoude, S.; Zink, M.C.; Clements, J.E.; Herzog, S.; Stitz, L.; Rott, R.; Narayan, O., 1992: Infection with Borna disease virus: molecular and immunobiological characterization of the agent. Borna disease virus (BDV), which seems to be distinct from all other known viruses, exhibits a unique mechanism of pathogenesis. This review highlights several aspects of the biology of infection with this virus and summarizes the preliminary char...

Richt J.; Meyermann R.; Stitz L., 1986: In vitro investigation on rat astrocytes infected with the neurotropic borna disease virus. Immunobiology 173(2-5): 419-420

Schneider, U., 2005: Novel insights into the regulation of the viral polymerase complex of neurotropic Borna disease virus. Borna disease virus (BDV) genetic information is encoded in a highly condensed non-segmented RNA genome of negative polarity. Replication and transcription of the genome occurs in the nucleus, enabling the virus to employ the cellular splicing mac...

Stahl, T.; Kacza, J.; Fluess, M.; Richt, J.A.; Seeger, J., 2000: Cytokine gene expression in the retina of Lewis rats infected with the neurotropic Borna disease virus. Journal of Neurovirology 6(5): 446, October

Herden, C.; Schluesener, H.J.; Richt, J.A., 2005: Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus. Experimental infection of Lewis rats with Borna disease virus (BDV) causes an immune-mediated nonpurulent meningoencephalitis. Viral persistence in the central nervous system is accompanied by mononuclear infiltrates, activated monocytic/microglia...

Stitz, L.; Schilken, D.; Frese, K., 1991: Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporine A-treated, immunosuppressed rats. In adult rats infected with Borna disease virus, the virus was found exclusively in the brain, whereas in cyclosporine A-treated rats, infectious virus was also detected in peripheral nerve fibers and, unexpectedly, in adjacent organ-specific cell...

Carbone, K.M.; Rubin, S.A.; Sierra Honigman, A.M.; Lederman, H.M., 1993: Characterization of a glial cell line persistently infected with Borna disease virus (BDV): influence of neurotropic factors on BDV protein and RNA expression. BDV replication was compared in neuronal (SK-N-SH and SK-N-SHEP) and astrocytic (C6) cell lines. While SK-N-SH cells produced more infectious virions per cell, the C6 cells contained more BDV proteins and RNA. BDV sequences in the supernatants of...

Tanaka, Y.; Primi, D.; Wang, R.Y.; Umemura, T.; Yeo, A.E.; Mizokami, M.; Alter, H.J.; Shih, J.W., 2001: Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family. A new group of transmissible single-stranded (ss) DNA viruses (SENV) distantly related to the large TT virus (TTV) family was recently identified. Eight different SENV isolates have been found, some with an association with posttransfusion hepatit...

de la Torre, J.C.; Carbone, K.M.; Lipkin, W.I., 1990: Molecular characterization of the Borna disease agent. Borna disease (BD) is a neurologic syndrome characterized by profound disturbances in behavior and the accumulation of specific antigens in limbic system neurons. The potency of brain homogenates from animals with BD to cause disease in normal ani...