+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cellular immune status of coronavirus-infected neonatal calves

Cellular immune status of coronavirus-infected neonatal calves

Comparative Immunology Microbiology & Infectious Diseases 17(2): 133-138

A preliminary study was conducted to determine the cellular immune status of neonatal, colostrum-deprived calves following inoculation with either attenuated or virulent bovine coronavirus (BCV). Uninfected calves served as controls. To determine the intestinal and systemic cellular immune status, we performed MHC-restricted cytotoxic lymphocyte (CTL) assay on mesenteric lymphocytes, enumerated T cell subsets in peripheral blood lymphocytes, and examined histopathological alterations in mesenteric lymph nodes and gut-associated lymphoid tissue. Target cells for the CTL assay were autologous testicular cells and effector cells were mesenteric lymphocytes from calves infected with BCV. No appreciable specific lysis was observed in any group of calves indicating the absence of demonstrable CTL responses. The T-c/T-s population was severely depressed in the calf inoculated with the virulent virus but not in those inoculated with either the attenuated virus or placebo. The mesenteric lymph nodes and Peyer's patches of calves inoculated with the virulent virus showed severe depletion of lymphocytes. These calves developed intestinal antibody responses in the acute phase of infection (1 week after infection) but were immunosuppressed in the later stage of infection.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 002317541

Download citation: RISBibTeXText

PMID: 7924246

DOI: 10.1016/0147-9571(94)90038-8

Related references

Effects of bovine coronavirus on cellular immune responses in neonatal calves. FASEB Journal 4(7): A1885, 1990

Antibody responses in spiral colon, ileum, and jejunum of bovine coronavirus-infected neonatal calves. Comparative Immunology Microbiology & Infectious Diseases 17(2): 139-149, 1994

Immune responses in spiral colon ileum and jejunum of coronavirus infected colostrum deprived calves. Abstracts of the Annual Meeting of the American Society for Microbiology 90: 128, 1990

A comparative evaluation of immune status in neonatal dairy calves. Indian Journal of Animal Sciences 56(2): 166-168, 1986

Humoral and cellular immune responses in turkey poults infected with turkey coronavirus. Poultry Science 80(10): 1416-1424, 2001

Cellular and humoral immune responses in calves experimentally infected with Salmonella dublin. Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. 1. Abt. Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie 249(4): 494-503, 1981

Oral nucleotides enhance immune status of neonatal dairy calves. Journal of Animal Science 84: 31-31, 2006

Cellular and humoral immune response of calves infected experimentally with bovine herpesvirus type 1. Veterinarnomeditsinski Nauki 24(8): 17-22, 1987

Effect on the growth rate and immune status in neonatal camel calves under different feeding practices. Journal Of Camel Practice And Research: 1, 35-38, 2008

Kinetics of SIV-specific cellular immune responses in SIV-infected neonatal rhesus macaques. Journal of Medical Primatology 30(4): 233, 2001

Cellular immune status in rodents infected with Litomosoides carinii. Indian Journal of Medical Research 82: 133-138, 1985

Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats. Bmc Veterinary Research 13(1): 92, 2017

Isolation of coronavirus from neonatal calves with pneumoenteritis in India. Veterinary Record 113(2): 47-47, 1983

Excretion and persistence of bovine coronavirus in neonatal calves. Archives of Virology 115(1-2): 127-132, 1990

Defined salmonella antigens for detection of cellular and humoral immune responses in salmonella infected calves. Research in Veterinary Science 33(2): 221-227, 1982