+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of high titer Edmonston-Zagreb, Biken-CAM and Schwarz measles vaccines in Peruvian infants

Comparison of high titer Edmonston-Zagreb, Biken-CAM and Schwarz measles vaccines in Peruvian infants

Pediatric Infectious Disease Journal 11(10): 822-827

In an effort to identify the optimal dose and strain of measles vaccination for early immunization, Peruvian infants were randomly assigned to receive one of three measles vaccines in varying doses at 5 to 6 or 8 to 9 months of age. Edmonston-Zagreb vaccines were significantly (P < 0.001) more immunogenic than equivalent or higher titers of Schwarz or Biken-CAM vaccines as determined by neutralization antibody response 3 months after vaccination. Eighty-two percent of infants who received high titer Edmonston-Zagreb vaccine at 5 to 6 months of age developed protective concentrations of measles antibody, a response rate similar to that observed after standard titer Schwarz (81%) or high titer Biken-CAM vaccine (81%) at 8 to 9 months of age. No significant differences in the rates of fever, rash or other adverse events were noted by vaccine group 10 to 14 days after vaccination. Although the high titer vaccines are more immunogenic in young infants than standard vaccines, long term safety must be assured before these vaccines can be put into widespread use.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 002328452

Download citation: RISBibTeXText

PMID: 1408479

DOI: 10.1097/00006454-199210000-00003

Related references

Comparison of Edmonston-Zagreb, Connaught and Schwarz measles vaccines in Cameroonian infants aged 3-8 months. Vaccine 13(3): 276-280, 1995

The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune responses in infants. Journal of Infectious Diseases 173(6): 1320-1326, 1996

Immunization of six-month-old infants with different doses of Edmonston-Zagreb and Schwarz measles vaccines. New England Journal of Medicine 322(9): 580-587, 1990

A comparison of vaccine efficacy and mortality during routine use of high-titre Edmonston-Zagreb and Schwarz standard measles vaccines in rural Senegal. Transactions of the Royal Society of Tropical Medicine and Hygiene 90(3): 326-330, 1996

Serological responses to two edmonston zagreb measles vaccines in 6 month olds infants and to schwarz measles vaccine in 9 month old infants. Program and Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy 32: 180, 1992

Measles antibody levels after vaccination with Edmonston-Zagreb and Schwarz measles vaccine at 9 months or at 9 and 18 months of age: a serological study within a randomised trial of different measles vaccines. Vaccine 31(48): 5766-5771, 2014

Immunization of 6 and 9 month old infants with AIK-C, Edmonston-Zagreb, Leningrad-16 and Schwarz strains of measles vaccine. International Journal of Epidemiology 23(5): 1069-1077, 1994

Measles antibody responses after early two dose trials in Guinea-Bissau with Edmonston-Zagreb and Schwarz standard-titre measles vaccine: Better antibody increase from booster dose of the Edmonston-Zagreb vaccine. Vaccine 19(15-16): 1951-1959, 28 February, 2001

Immunogenicity of high-titre AIK-C or Edmonston-Zagreb vaccines in 3.5-month-old infants, and of medium- or high-titre Edmonston-Zagreb vaccine in 6-month-old infants, in Kinshasa, Zaire. Vaccine 12(14): 1311-1316, 1994

Trials of Edmonston-Zagreb measles vaccine in guinea-Bissau: Serological responses following vaccination with Edmonston-Zagreb strain at 4-8 months versus vaccination with Schwarz strain at 9-12 months of age. Vaccine 12(11): 1026-1031, 1994

Comparative serological efficacy of the measles vaccine strains Edmonston-Zagreb, Schwarz and AIK-C in Togolese infants of 4-5 months and 8-10 months. Bulletin de la Societe de Pathologie Exotique 84(5 Pt 5): 873-884, 1991

Long term impact of high titer Edmonston-Zagreb measles vaccine on T lymphocyte subsets. Pediatric Infectious Disease Journal 13(2): 109-112, 1994

Comparative results of the immunogenicity of Edmonston-Zagreb and Schwartz measles vaccines administered to 60 Egyptian infants. Journal of the Egyptian Public Health Association 67(1-2): 27-36, 1992

Immunogenicity of high-titer Edmonston-Zagreb measles vaccine in human immunodeficiency virus-infected children in Kinshasa, Zaire. Journal of Infectious Diseases 167(6): 1418-1421, 1993

Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months. Lancet 2(8676): 1357-1360, 1989