+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Differential cardiac histopathology in inbred mouse strains chronically infected with Trypanosoma cruzi



Differential cardiac histopathology in inbred mouse strains chronically infected with Trypanosoma cruzi



Journal of Parasitology 78(6): 1059-1066



Seven inbred mouse strains were examined for the presence of chronic Chagas' cardiomyopathy in postacute Trypanosoma cruzi infection. DBA/1, DBA/1, BALB/c, B10.T (6R), B10.Q, B10.D2, and B6 mice were infected for 100 days with the Brazil strain of T. cruzi. Standard histologic examination of cardiac tissue from these mice revealed the following relationship among the different strains based on the severity of observed inflammation (myocarditis): BALB/c, DBA/1, and DBA/2 were the most inflamed; B10.T (6R) and B10.Q were intermediate; and B6 and B10.D2 showed the least inflammation. Examination of these tissues for characteristics of myocardiopathy such as cell swelling, edema, vacuolization, necrosis, myocytolysis, connective tissue infiltration, and thinning of the right ventricular wall indicated a relative relationship among the different strains relative to the severity of cardiomyopathy as follows: BALB/c, DBA/2, and DBA/1 showed the most cardiopathy (pathopermissive); B10.T (6R) and B10.Q showed intermediate pathology; and B6 and B10.D2 showed the least involvement (pathoresistant). Anti-heart antibody present in the sera of all these mice showed specific reactivity in western blots to a 43-kDa glycoprotein from normal heart tissue. Also, anti-heart antibody enzyme-linked immunosorbent assay titers for all mouse strains were similar and showed no correlation with the severity of tissue damage. The fact that different inbred strains show various degrees of myocarditis and cardiomyopathy may be useful in the study of pathogenesis of chronic Chagas' disease. Results from this limited list of inbred strains suggest that background genes, rather than the major histocompatibility complex, play the major role in the expression of cardiac pathogenesis. Correlation of acute parasitemia level with degree of chronic damage was indicated in pathopermissive strains (BALB/c and DBA/2), which had higher parasitemia levels than the pathoresistant (B6 and B10.D2).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 002346030

Download citation: RISBibTeXText

PMID: 1491299

DOI: 10.2307/3283230


Related references

Anti heart response and histopathology in resistant inbred mouse strains chronically infected with trypanosoma cruzi. FASEB Journal 5(5): A1365, 1991

Immunological response of six inbred mouse strains infected by three different stains of trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 80(2): 203-212, 1985

In situ characterization of the myocardial inflammatory infiltrate in different mouse inbred strains infected with Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 94(Suppl. 2): 171, 1999

Pathology affects different organs in two mouse strains chronically infected by a Trypanosoma cruzi clone: a model for genetic studies of Chagas' disease. Infection and Immunity 72(4): 2350-2357, 2004

Electrophysiological and histopathological alterations in inbred mice chronically infected with trypanosoma cruzi clones. Memorias do Instituto Oswaldo Cruz 81(Suppl.): 49, 1986

Heart damage comparing three strains of mice chronically infected with Trypanosoma cruzi. Medicina 47(5): 493-499, 1987

Chronotropic responses to acetylcholine in atria of mice chronically infected with Y and CL strains of Trypanosoma cruzi. Brazilian Journal of Medical and Biological Research 21(5): 1019-1021, 1988

Cardiac enzyme activities in mice chronically infected with Trypanosoma cruzi. Cellular and Molecular Biology 29(5): 415-420, 1983

Lymphokine release by spleen cells from trypanosoma cruzi infected inbred strains of mice. Molecular & Biochemical Parasitology (Suppl.): 29, 1982

Cardiac neuronal depopulation in hamsters (Mesocricetus auratus) chronically infected with Trypanosoma cruzi. Revista Da Sociedade Brasileira de Medicina Tropical 32(1): 35-39, 1999

Reversibility of cardiac fibrosis in mice chronically infected with Trypanosoma cruzi, under specific chemotherapy. Memorias do Instituto Oswaldo Cruz 86(2): 187-200, 1991

Heterogeneity in the plasma levels of two acute-phase proteins in mice from inbred strains infected with Trypanosoma cruzi. Parasitology Research 80(5): 439-441, 1994

Trypanosoma (Schizotrypanum) cruzi: histopathology in mice infected with strains isolated from Didelphis marsupialis from the valley of Caracas (Venezuela). Acta Cientifica Venezolana 47(4): 244-247, 1996

Trypanosoma cruzi: regulation of mitogenic responses during infection in genetically resistant and susceptible inbred mouse strains. Experimental Parasitology 59(1): 33-43, 1985

Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi. American Journal of Tropical Medicine and Hygiene 93(5): 976-982, 2015