EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of different protein diets on the distribution of amino acids in plasma, liver and brain in the rat


Annals of Nutrition & Metabolism 36(1): 23-33
Effect of different protein diets on the distribution of amino acids in plasma, liver and brain in the rat
The distribution of amino acids between plasma, liver and brain was studied in adult male rats, fed a diet containing 8.7, 17 (control animals), 32 and 51% of protein during 15 days. The caloric intake was nearly equal in all groups. The highest food intake was observed in the animals on the low protein diet. Changes in plasma amino acids were variable. In contrast to the behavior of most amino acids in plasma, the branched chain amino acids were highest in the animals fed the 51% protein diet. Despite the low protein intake in the animals fed a 8.7% protein diet, the concentration of serine, glutamic acid, glutamine, glycine, alanine, methionine, isoleucine, leucine, phenylalanine and ornithine were significantly higher compared to control animals, whereas in those receiving a high protein diet, valine, leucine, tyrosine, tryptophan and histidine increased in relation to the increased protein and amino acid intake. The plasma amino acid patterns are not greatly influenced by the amino acid distribution in the food and the amount ingested. Alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase and cholinesterase showed a two- to fivefold increased activity in the liver of animals consuming a high protein diet. In the brain, the concentration of valine, leucine, isoleucine, phenylalanine and tyrosine in animals receiving the low protein diet was higher than in controls and increased further with increasing protein content of the diet. Glutamine was increased in all dietary groups. The predicted influx of amino acids showed increasing influx rates in dependence of the plasma amino acid concentration. The entry of tyrosine and tryptophan and their brain concentration was inversely proportional to the protein content of the diet. In the present study which considers long-term adaptation to an increasing protein and amino acid intake in comparison to a balanced control protein diet, the levels of the indispensable amino acids were maintained within narrow limits in the brain and liver. The results indicate that inspite of a variable protein intake, the body tends to keep organ amino acids in relatively narrow limits favoring in this way amino acid homeostasis.

(PDF same-day service: $19.90)

Accession: 002355101

PMID: 1590669

DOI: 10.1159/000177695



Related references

1. Effect of source of dietary nitrogen on nitrogen balance and on plasma and urinary amino acids of man. 2. Effect of high protein or amino acid imbalanced diets on food intake, growth, serine dehydratase activity and plasma amino acids in growing rats. Dissertation Absts. Internat. (B). 30: 1774B, 1969

Relation between liver amino acid-catabolizing enzymes and free amino acids of liver and plasma in adult cockerels fed diets containing graded levels of protein. Journal of Nutrition 107(5): 829-833, 1977

Effect of the frequency of distribution of a protein supplement to a protein free or a hypoproteic diet on rat growth. food efficiency, body composition, liver nucleic acids and proteins, plasma free amino acids. Annales de recherches veterinaires: (1) 99-114, 1978

Effect of the frequency of distribution of a protein supplement to a protein free or a hypo proteic diet on the rat growth food efficiency body composition liver nucleic acids and proteins plasma free amino acids. Annales de Recherches Veterinaires 9(1): 99-114, 1978

Effect of the frequency of distribution of a protein supplement combined with a protein-free or low-protein diet on rat development. Nutritional effectiveness, body composition, liver nucleic acid and protein content, free plasma amino acids. Annales de Recherches Veterinaires. Annals of Veterinary Research 9(1): 99-114, 1978

Studies related to protein synthesis in experimental animals fed atherogenlc diets in Free amino acids in plasma and liver, and C14-glyclne incorporation into plasma and structural proteins of rats. 1966

Studies related to protein synthesis in experimental animals fed atherogenic diets. 3. Free amino acids in plasma and liver, and 14C-glycine incorporation into plasma and structural proteins of rats. Experimental and Molecular Pathology: Suppl 3:96-107, 1966

Effect of different amounts of dietary protein and added synthetic lysine on amino acids in plasma of fattening pigs. 2. Total plasma amino acids and the ratio of essential to nonessential amino acids. Biologizace a Chemizace Vyzivy Zvirat 13(3): 229-232, 1977

Study on the effect of amino acids on dietary fatty liver. 2. Amount of additional amino acid preparations in low-protein and low-fat diets. Nihon Shonika Gakkai Zasshi. Acta Paediatrica Japonica 72(4): 460-467, 1968

Effect of low-protein diets on free amino acids in plasma of young men: effect of protein quality with maintenance or excess energy intake. Journal of Nutritional Science and Vitaminology 24(3): 297-309, 1978