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Effect of diphenhydramine and promethazine on PMSG-induced ovulation in immature rats

, : Effect of diphenhydramine and promethazine on PMSG-induced ovulation in immature rats. Iraqi Journal of Veterinary Sciences 6(2): 88-91

At 27 days of age, female rats (8-11 per group) received no treatment (controls) or were injected with 20 IU PMSG, followed by no further treatment or daily injections of 10 mg/kg of an antihistamine (diphenhydramine or promethazine) on days 27, 28 and 29. All were killed on day 30, and their ovaries were examined. Both antihistamines significantly reduced the increase in ovarian weight and blocked ovulation in PMSG-treated but had no significant effect on uterus weight.

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Related references

de la Lastra, M.; Forcelledo, M.L., 1973: Stimulatory effect of L-vasopressin on PMSG-induced ovulation in immature rats. The work was undertaken to examine the possibility that vasopressin may be involved in the regulation of gonadotropin secretion. Injections of L-vasopressin enhanced the ovulatory response of immature rats to PMSG. This type of ovulation occurred...

Peluso, J.J.; Stude, D.; Steger, R.W., 1980: Role of androgens in hCG-induced ovulation in PMSG-primed immature rats. The effect of pretreatment with cyproterone acetate and Flutamide on HCG-induced ovulation was studed in PMSG-primed immature females . Pretreatment with either anti-androgen reduced the ovulation rate by 50%. Not all preovulatory follicles in unt...

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