EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of drug formulation and feeding on the pharmacokinetics of orally administered quinidine in the horse






Journal of Veterinary Pharmacology & Therapeutics 17(4): 275-278

Effect of drug formulation and feeding on the pharmacokinetics of orally administered quinidine in the horse

Quinidine is the drug of choice for the treatment of cardiac arrhythmias in horses. The plasma concentrations vs. time profiles following oral administration of two formulations of quinidine sulphate, an oral solution and an oral suspension paste, were evaluated in nine horses. They received multiple administrations of the oral solution under fed and non-fed conditions and of the paste under non-fed conditions. A loading dose of 20 mg cntdot kg-1 and a maintenance dose of 10 mg cntdot kg-1 quinidine with dosing interval of 6 h were used. The relative bioavailability of the oral solution under fed conditions in comparison to the solution under non-fed conditions was 75.0 +- 10.2% for the loading dose and 97.18 +- 31.66% after the fourth dose. For the paste formulation the relative bioavailability values are riot reported, as steady-state levels were not reached. There was a large variation in plasma quinidine levels when the paste formulation was administered. Feeding conditions had a significant influence on the C-max values after administration of the loading dose. The T-max values were not affected by food intake. It, was concluded that an oral solution has to be preferred because of the variable drug bioavailability from the paste formulation and the poor acceptability of the paste by the horse.

Accession: 002355262

PMID: 7966546

DOI: 10.1111/j.1365-2885.1994.tb00245.x

Download PDF Full Text: Effect of drug formulation and feeding on the pharmacokinetics of orally administered quinidine in the horse



Related references

Effect of feeding on the fate of orally administered phenylbutazone, trimethoprim and sulphadiazine in the horse. Veterinary Record 115(23): 599-600, 1984

Absorption of phenylbutazone from a paste formulation administered orally to the horse. Research in Veterinary Science 41(2): 200-206, 1986

Effects of formulation on the pharmacokinetics of orally administered pinacidil in humans. Journal of Pharmaceutical Sciences 76(12): 940-941, 1987

Pharmacokinetics of a new orally soluble film formulation of sildenafil administered without water. International Journal of Clinical Pharmacology and Therapeutics 52(6): 437-445, 2014

Pharmacokinetics of the injectable formulation of methadone hydrochloride administered orally in horses. Journal of Veterinary Pharmacology and Therapeutics 32(5): 492-497, 2009

Pharmacokinetics of an orally administered methylcellulose formulation of gallium maltolate in neonatal foals. Journal of Veterinary Pharmacology and Therapeutics 33(4): 376-382, 2011

The pharmacokinetics of the intravenous formulation of fentanyl citrate administered orally in children undergoing general anesthesia. Anesthesia and Analgesia 99(5): 1347-51; Table of Contents, 2004

Itraconazole increases plasma concentrations of orally administered quinidine A decrease in the metabolism and renal clearance of quinidine. European Journal of Clinical Pharmacology 52(SUPPL ): A134, 1997

Influence of feeding schedule on the absorption of orally administered flunixin in the horse. Equine Veterinary Journal 24(Supplement 11): 62-65, 1992

Pharmacokinetics of a New Orally Disintegrating Tablet Formulation of Aripiprazole 15 mg Administered Without Water in Healthy Middle-aged Korean Subjects. Clinical Therapeutics 37(12): 2772-2779, 2016