+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of ephedrine and theophylline on weight loss, resting energy expenditure and lipoprotein lipase activity in obese over-fed rats

, : Effect of ephedrine and theophylline on weight loss, resting energy expenditure and lipoprotein lipase activity in obese over-fed rats. International Journal of Obesity and Related Metabolic Disorders 17(6): 343-347

The effect of ephedrine (E) and theophylline (T), administered alone and in combination (E/T), on weight loss, resting energy expenditure and post-heparin lipoprotein lipase activity in plasma (PHLA) and in adipose tissue (ATLP) were investigated in obese over-fed rats, who had been diet restricted (-40% of normal caloric intake) for three weeks. E, T and E/T significantly increased weight loss in all experimental groups as compared to the controls. Weight loss was achieved not only by preventing the adaptive fall in resting energy expenditure associated with diet restriction, but by raising it above basal level. The effect of E/T mixture was no greater than that of E or T alone. E, T and E/T administration increased PHLA in plasma while hypocaloric diet alone did not influence the activity of the enzyme. ATLP in the epididymal fat pads decreased insignificantly in all experimental groups, as well as in the controls. Serum cholesterol levels were not influenced by hypocaloric diet and by drug administration, but serum triglycerides increased significantly in E, T and E/T treated groups. The elevation of PHLA after ephedrine and/or theophylline administration was mostly due to an increase in the hepatic lipase (HL) level. This enzyme contributes to the removal of the atherogenic intermediate density lipoproteins from blood serum. The increased HL activity in drug-treated, diet-restricted obese rats may therefore play a role in the prevention of atherosclerosis.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002355417

PMID: 8392500

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Slaski, Jan J.; Archambault, Daniel J.; Li, Xiaomei; Macyk, Terry, 2002: Evaluation of functional diversity of microbial communities in soils using the biolog system. Communications in Soil Science & Plant Analysis 33(15-18): 2392-2393, September-October

Falta, W., 1943: Types of emaciation and obesity. An account is given of the different endocrine disturbances causing excessive loss or gain in weight. In conclusion the author remarks that insulin is the only hormone of importance for increasing weight and thyroid extract the only one for decrea...

Stubblefield, B.; Sidransky, E., 1992: Dried umbilical cords as a source of DNA for genetic studies. American Journal of Human Genetics 51(4 SUPPL ): A390

Novas, Fernando E.; Kundrat, Martin; Agnolin, Federico L.; Ezcurra, Martin D.; Ahlberg, Per Erik; Isasi, Marcelo P.; Arriagada, Alberto; Chafrat, Pablo, 2012: A new large pterosaur from the Late Cretaceous of Patagonia. Journal of Vertebrate Paleontology 32.6

Harris, R.L.; George, J.E.; Ahrens, E.H.; Davey, R.B.; Bazan, H.O., 1988: Selection for resistance to coumaphos in a strain of southern cattle tick (Acari: Ixodidae). A strain of Boophilus microplus (Canestrini) collected near Tuxla Gutierrez, Chiapas, Mexico, was subjected to selection pressure for increased resistance to coumaphos by exposing larvae from individual egg masses to treated paper. Untreated sibli...

Anonymous., 1976: Dynamique des populations: remarques generales et vue d'ensemble sur des etudes concernant des pectinides, des ostreides, des brachiopodes et des crinoides. Travaux Lab Paleont Univ Paris CERPAB notes contr, 2: 1-43

Niiler, Eric, 2000: Island survivors On what once was a North American Galapagos, researchers try to save devastated wildlife. Scientific American 283(2): 18-20, August

Garza Trasobares E.; Villeta Caraballo E.; Suarez De Parga J.M.; Segura Cabral J.M.; Agulla A., 1987: Spontaneous bacterial peritonitis due to aeromonas hydrophila presentation of two cases. Revista Espanola de las Enfermedades del Aparato Digestivo 72(6): 743-744

Grossbeck, J. A., 1911: A new Canadian geometrid. Canadian Entomologist, 43 225

Kimura T., 1972: Effect of male hormone on sex cycle of mouse part 3. Zoological Magazine (Tokyo) 81(4): 345-346