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Effect of experimentally induced endotoxemia on serum interleukin-6 activity in horses

, : Effect of experimentally induced endotoxemia on serum interleukin-6 activity in horses. American Journal of Veterinary Research 53(5): 753-756

A study was conducted to determine whether serum interleukin-6 (IL-6) activity increased in horses during experimentally induced endotoxemia and whether serum IL-6 activity correlated to changes in clinical or laboratory data. Six clinically normal horses were given endotoxin IV (30 ng/kg of body weight) in 0.9% NaCl solution over 1 hour. Five of these and 1 additional horse served as controls and were given only 0.9% NaCl solution. Venous blood, for determination of serum IL-6 activity and WBC count, was collected before and at various times through 8 hours after the start of endotoxin or NaCl infusion. Rectal temperature and heart and respiratory rates were recorded throughout the study period. Serum IL-6 activity was determined by bioassay of proliferation of the B13.29 clone B.9 hybridoma cell line. From 1.5 through 5 hours after start of the infusion, serum IL-6 activity was significantly (P less than 0.05) increased in horses given endotoxin. Mean peak serum IL-6 activity was observed between 3 and 4 hours. In response to endotoxin infusion, horses became lethargic, tachycardic, and febrile. Leukopenia developed by 1 hour, followed by leukocytosis at 8 hours. Significant (P less than 0.05) positive association and linear correlation were apparent between mean serum IL-6 activity and mean rectal temperature in the group of horses that were given endotoxin. Changes from baseline were not evident in any of the clinical or laboratory values in horses given only NaCl solution.

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Accession: 002355531

PMID: 1524301

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Gonzalez-Rodriguez, E., 1991: A ressurgencia de Cabo Frio RJ, Brasil fertilidade e fatores nutricionais limitantes da biomassa fitoplanctonica. Revista Brasileira de Biologia 51.2: 471-486

Zaharenkov, F. E.; Seleznev, Ju. N., 1967: An automatic separator for a longitudinal flow of logs. Describes the design of a separator developed to distribute logs on a conveyor to both sides to form two separate flowlines for further processing (barking, cross-cutting, etc.).

Shulman, S.; Menezo, V.; Comer, M.; Lightman, S., 2003: Outcomes of chronic immunosuppression for chronic uveitis. Purpose: Retrospective evaluation of outcome following immunosuppressive treatment in patients with chronic non-infectious intermediate and posterior uveitis who did not respond to or did not tolerate treatment with corticosteroids alone. Methods:...

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Peters N.S.; Smith J.H.; Green C.R.; Severs N.J., 1991: Altered patterns of gap junction distribution in ischemic heart disease. European Heart Journal 12(ABSTR SUPPL): 211

Hamlett, W.C.; Allen, D.J.; Stribling, M.D.; Schwartz, F.J.; Didio, L.J., 1985: Permeability of external gill filaments in the embryonic shark. Electron microscopic observations using horseradish peroxidase as a macromolecular tracer. External gill filaments of sharks are purely transient embryonic structures. They contain a single vascular sinusoidal loop that is continuous with the afferent and efferent branchial arteries. Each filament is comprised of a squamous epithelial b...

Ledeboer, A. M.; Bezemer, S.; Haard, J. J. W. de; Schaffers, I. M.; Verrips, C. T.; Vliet, C. van; Dusterhoft, E. M.; Zoon, P.; Moineau, S.; Frenken, L. G. J., 2002: Preventing phage lysis of Lactococcus lactis in cheese production using a neutralizing heavy-chain antibody fragment from llama. Bacteriophage infection is still a persistent problem in large dairy processes despite extensive studies over the last decades. Consequently, new methods are constantly sought to prevent phage infection. In this paper, we show that phage neutraliz...

Polder, WN., 1973: Pflege und Fortpflanzung von Deudrobates azureus und anderer Dendrobatiden. Aquarien Terrar Z: 2612: 424-428