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Effect of fasting, self-selected and isocaloric glucose and fat meals and intravenous feeding on plasma zinc concentrations


Annals of Clinical Biochemistry 28: 442-445
Effect of fasting, self-selected and isocaloric glucose and fat meals and intravenous feeding on plasma zinc concentrations
This study investigated the effect of fasting, self-selected meals and isocaloric oral glucose and fat meals and intravenous (i.v.) feeding on plasma zinc concentrations in men. Plasma zinc remained stable when volunteers fasted all day, but self-selected meals and 600 kCal of dextrose or fat emulsion caused significantly reduced plasma zinc concentrations [mean (SD) 12.1 (1.4), 12.3 (0.6) and 12.2 (0.7) .mu.mol/L at 1400 h, respectively, compared with a fasting level of 13.9 (1.6) .mu.mol/L at 0800 h, P < 0.05]. In patients undergoing intravenous hyperalimentation, plasma zinc decreased from 12.0 (1.4) .mu.mol/L at 0800 h to 10.0 (1.1) .mu.mol/L at 1400 h [mean (SD), P < 0.01]. These data show that both enteral and i.v. feeding cause a decline in plasma zinc and that glucose alone is not responsible for this post-prandial fall since ingestion of isocaloric amounts of glucose or fat have a similar effect.


Accession: 002355600

PMID: 1958045

DOI: 10.1177/000456329102800503



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