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Effect of fish oil and coconut oil diet on the LDL receptor activity of rat liver plasma membranes

, : Effect of fish oil and coconut oil diet on the LDL receptor activity of rat liver plasma membranes. Biochimica et biophysica acta: International journal of biochemistry and biophysics, 1083(3): 298-304

The influence of 4 weeks treatment with fish oil and coconut oil enriched diets on the chemical composition of rat liver plasma membranes and LDL and on the binding of LDL to liver membranes was investigated. Rats fed fish oil diet showed a total, LDL and HDL plasma cholesterol concentration lower than the values observed in rats fed coconut oil and to a lesser extent lower than those of rats fed standard laboratory diet. LDL of rats on fish oil diet had a relative percentage of cholesterol and phospholipid lower, while that of triacylglycerol was greater. Furthermore, fish oil feeding was associated with a greater concentration of n - 3 fatty acids and a lower arachidonic and linoleic acid content in LDL. Liver plasma membranes isolated from fish oil rats showed a higher percentage of n - 3 fatty acids, while only, a trace amount of these fatty acids was found in control and coconut oil fed animals. in binding experiments performed with LDL and liver membranes from fish oil fed rats and control rats, binding affinity (Kd = 3.47 +/- 0.93 and 4.56 +/- 1.27, respectively) was significantly), higher (P < 0.05) as compared to that found using membranes and lipoprotein from coconut oil fed rats (Kd = 6.82 +/- 2.69). In cross-binding experiments performed with fish oil LDL and coconut oil liver plasma membranes or coconut oil LDL and fish oil liver plasma membranes, the LDL binding affinity was comparable and similar to that found in fish oil fed animals. No difference was found in the Bmax among all the groups of binding experiments. Our data seem to indicate that during fish oil diet the higher binding affinity of LDL to liver plasma membranes might be partly responsible of the hypocholesterolemic action of marine oil rich diet as compared to saturated diet. Furthermore, the modifications of binding affinity induced by changes of LDL and membrane source, suggest that lipoprotein and liver plasma membrane composition may be an important variable in binding studies.

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Accession: 002355839

DOI: 10.1016/0005-2760(91)90086-w

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Other references

Mori, T., 1971: Pregnanolone and 20 -hydroxypregn-4-en-3-one (20 -OH-P) in prolonging gestation in the rat. Acta Medicinae Okayama 25(3): 189-191

Wennerberg, A.; Sawase, T.; Kultje, C., 1999: The influence of CarisolvTM on enamel and dentine surface topography. The purpose of the present study was to investigate the surface topography of healthy enamel and dentine before and after application of a new chemomechanical system for caries removal, CarisolvTM. The same surfaces were investigated with respect...

de Vos, R.H.; van Dokkum, W.; Olthof, P.D.; Quirijns, J.K.; Muys, T.; van der Poll, J.M., 1984: Pesticides and other chemical residues in Dutch total diet samples (June 1976-July 1978). Over a period of 2 yr 126 different food items of a market basket of 16-18-yr old males were purchased every 2 months. The foodstuffs were prepared as for eating, and were combined in 12 commodity groups. Twelves samples of each food group were ho...

Sossin, W.S.; Fisher, J.M.; Scheller, R.H., 1989: Cellular and molecular biology of neuropeptide processing and packaging. Neuron 2(5): 1407-1417

Olusanya, O., 1991: Immunological response to Helicobacter pylori among Nigerians. Among 420 Nigerians examined, 39% had antibodies to Helicobacter pylori. The prevalence was significantly higher in males (55%) than in females (29%). The prevalence tended to rise with age in both sexes and was significantly higher in the 30-34 y...

King E. C., 2000: The crustal structure and sedimentation of the Weddell Sea embayment; implications for Gondwana reconstructions. The Weddell Sea embayment is central to reconstructions of the West Antarctic region of Gondwana. Some reconstructions represent this area as a pre-break-up component, the Filchner block, defined by the present 2000 m isobath and coastline but tak...

Jang, S-Soo.; Royston, S.E.; Lee, G.; Wang, S.; Chung, H.Jung., 2016: Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity. Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Pathologic accumulation of soluble amyloid-β (Aβ) oligomers impairs synaptic plasticity and causes epileptic seizures, both of which co...

Marler, J.; Enz, C., 1993: Child-care programs that make sense. The best employers provide child-care resources to their employees because it makes good business sense to do so. There are three approaches to providing child-care resources: offer services, supply information (the most popular method), and offer...

Anonymous, 1991: If at first you do succeed. Lancet 337(8742): 650-651

Martin, D.A.; Miller, S.D.; Alley, H.P., 1988: Barley (Hordeum vulgare) response to herbicides applied to three growth stages. In trials at Torrington, Wyoming during 1984-85, in which the response of irrigated spring barley cv. Steptoe to herbicides applied at the 2- to 4-leaf, fully tillered and boot stages was evaluated, 0.02 kg chlorsulfuron and 0.55 kg MCPA-amine/ha...