EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of fluconazole prophylaxis on fever and use of amphotericin in neutropenic cancer patients


, : Effect of fluconazole prophylaxis on fever and use of amphotericin in neutropenic cancer patients. Chemotherapy 40(2): 136-143

We studied the impact of fluconazole prophylaxis (400 mg/day) on clinical features including fever and use of amphotericin in a randomized, double-blind, placebo-controlled (1:1 randomization) study among patients undergoing chemotherapy for leukemia and those undergoing bone marrow transplantation. Fluconazole or placebo was given throughout the period of neutropenia. Amphotericin was administered to 5 of 23 (22%) fluconazole recipients and 14 of 23 (58%) placebo recipients (p lt 0.01). Median duration of amphotericin used in fluconazole and placebo groups was 9 days (mean 10.8) and 13 days (mean 14) respectively. Patients who received fluconazole had significantly shorter duration of fever prior to treatment with amphotericin (days, median 5 vs. 9, p lt 0.05). Superficial fungal infections were noted in 8 (34%) fluconazole recipients and 19 (79%) placebo recipients (p = 0.002). Fluconazole was well tolerated. Prophylaxis with fluconazole resulted in a significant reduction in the empiric use of amphotericin, duration of fever and incidence of superficial fungal infections.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002355876

DOI: 10.1159/000239184

PDF Full Text: Effect of fluconazole prophylaxis on fever and use of amphotericin in neutropenic cancer patients


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Buinitskii V.K., 1968: Effect of microscopic algae on the structure and strength of antarctic sea ice diatoms. Okeanologiya 8(6): 971-979

Cook, T.A.; Urrutia, R.; McNiven, M.A., 1994: Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. Dynamin is a 100-kDa microtubule-activated GTPase originally isolated from mammalian brain that has been proposed to be crucial in the early steps of endocytosis. Previous studies on the primary structure, biochemical properties, and functional ro...

Frederking, U., 1975: Emotional conditions and behavior disorders in 10-year schoolchildren (results of a social medicine study, II). Praxis der Kinderpsychologie und Kinderpsychiatrie 24(7): 258-265

Muramatsu, A.; Azuma, T.; Okajima, T.; Ohtani, M.; Dojo, M.; Yamazaki, Y.; Kuriyama, M., 2004: Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan. Background: Effective therapy for gastro-oesophageal reflux disease (GERD) is associated with improvement in health-related quality of life. It remains unclear whether Helicobacter pylori infection protects against GERD. Aim: We evaluated the rela...

Santamaria R.; Pourrias B.; Benveniste J., 1983: Effects of paf acether platelet activating factor of the isolated portal vein of the rat. Journal de Pharmacologie (Paris) 14(SUPPL 1): 83

Muro, Y.; Ishikawa, A.; Sugiura, K.; Akiyama, M., 2012: Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies. Myositis-specific autoantibodies (MSAs), which characterize certain forms of inflammatory myopathy, are useful in the diagnosis and prediction of prognosis in DM/PM. Anti-transcriptional intermediary factor 1-α (TIF1-α) antibodies were recently...

Cuellar, A.Evans.; Markowitz, S.; Libby, A.M., 2004: Mental health and substance abuse treatment and juvenile crime. There is a large body of literature examining the determinants of juvenile crime, which highlights economic, family, peer, and educational factors associated with delinquency and recidivism, and the important roles of social service and educationa...

Schurian, G.; Naessig, W.A., 2002: Over 100 years of the Apollo Entomological Society in Frankfurt am Main - look back and outlook Ueber 100 Jahre Entomologischer Verein Apollo eV in Frankfurt am Main - ein Rueckblick und Ausblick. Nachrichten des Entomologischen Vereins Apollo. Februar; 22: 1-72 (Sonderheft)

Hjalgrim, L.Lyngsie.; Rostgaard, K.; Engholm, G.; Pukkala, E.; Johannesen, T.Børge.; Ólafsdóttir, Eínborg.; Hjalgrim, H., 2015: Aetiologic heterogeneity in pediatric Hodgkin lymphoma? Evidence from the Nordic countries, 1978-2010. In epidemiological studies, Hodgkin lymphomas (HL) in children younger than 15 years and HL in adolescents and younger adults age 15-35 years has traditionally been studied separately, under the assumption that HL at age 0-14 constitute a homogene...

Fukado, Y., 1966: Transplantation of the cilia. Ganka. Ophthalmology 8(6): 489-494