+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of formulation on the pharmacokinetics and efficacy of doramectin

, : Effect of formulation on the pharmacokinetics and efficacy of doramectin. Veterinary Parasitology 49(1): 17-26

The pharmacokinetics of doramectin, a novel avermectin, were evaluated following parenteral administration in a range of oil-based formulations in an attempt to optimise the formulation. Therapeutic and persistent efficacies against Cooperia oncophora were also evaluated. This approach led to the identification of formulations based upon sesame oil and ethyl oleate which gave more prolonged doramectin plasma concentrations with no loss in therapeutic efficacy and improved persistent efficacy following subcutaneous administration to cattle at a dosage of 200 mu-g kg-1. The importance of using both pharmacokinetic and efficacy end points to distinguish between formulations is discussed. All formulations were well tolerated as evidenced by the absence of any reaction to injection either in the form of behavioural responses, injection site swelling or postmortem lesions. Sesame oil with ethyl oleate was the best parenteral vehicle tested for doramectin, allowing the expression of a high level of therapeutic and persistent efficacy and offering the benefit of excellent injection site toleration.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002355991

PMID: 8236734

DOI: 10.1016/0304-4017(93)90219-d

Download PDF Full Text: Effect of formulation on the pharmacokinetics and efficacy of doramectin

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Herman Y., 1973: Bolivina arctica new species a new benthonic foraminifera from arctic ocean sediments. Journal of Foraminiferal Research 5(3): 137-141

Backman K.C., 1989: Method of biosynthesis and cells therefor us patent 4839286 june 13 1989. Official Gazette of the United States Patent & Trademark Office Patents 1103(2): 1231

Sharma, R.K.; Pandey, H.K., 1972: Economics of guava production and its marketing. A study of average costs and returns/ha of a guava orchard in Allahabad, inclusive of intercrops.

Hoeksema, J.; Munski, J., 1997: Development of a patient-centered preprocedure program. Staff members at Blodgett Memorial Medical Center, Grand Rapids, Mich, developed and implemented a prototype for a new patient-centered preadmission testing (PAT) program. Using continuous improvement principles, an implementation team improved th...

German, V.A.; Gavrilova, M.S.; Leshchenko, V.M.; Pavlova, G.V., 1979: Use of potassium iodide iontophoresis in the treatment of women suffering from candidiasis of the genital mucosa. Vestnik Dermatologii i Venerologii: 54-57

Asif, M.; Abasaeed, A.E., 1998: Modeling of glucose isomerization in a fluidized bed immobilized enzyme bioreactor. A heterogeneous model describing the glucose isomerization process in an immobilized enzyme, fluidized-bed bioreactor was developed. The model without any adjustable parameters was used to predict the isomerization process. An excellent agreement...

Gaul, D.F.; Davidson, M.W.; Palmer, G.; Shaw, R.W.; Knaff, D.B., 1988: Spectroscopic and ligand-binding properties of an oxygen-binding heme protein from Chromatium vinosum. Magnetic circular dichroism spectra were obtained for the oxidized and reduced forms of cyanide, azide and carbon monoxide complexes of an O2-binding hemeprotein isolated from the photosynthetic purple sulfur bacterium, Chronatium vinosum. Cyanide...

Mazziotti, A.; Mazzotti, F.; Pantusa, M.; Sportelli, L.; Sindona, G., 2006: Pro-oxidant activity of oleuropein determined in vitro by electron spin resonance spin-trapping methodology. In this work, the pro-oxidant behavior of oleuropein (OLP, 1) is characterized in a Fenton-like experiment by means of ESR spectroscopy using the spin trap system DMSO and 4-(pyridyl-1-oxide)-N-tert-butyl nitrone (POBN) in phosphate buffer (PB) so...

Tate Marcus C.; Johnson Scott E., 2000: Subvolcanic and deep-crustal tonalite genesis beneath the Mexican Peninsular Ranges. Cretaceous (115-103 Ma) tonalites throughout the western Peninsular Ranges Batholith of Baja California can be explained as hybrids between andesitic fractionates ( approximately 65%) and dehydration melts of amphibolite ( approximately 35%). Mixi...

Sainsbury, R.; Atac Trialists' Group, 2002: Anastrozole is superior to tamoxifen in the treatment of post-menopausal women with early breast cancer First results of the ATAC trial. International Journal of Cancer Supplement (13): 137