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Effect of ileal oleate on interdigestive intestinal motility of the dog



Effect of ileal oleate on interdigestive intestinal motility of the dog



Digestive Diseases & Sciences 39(7): 1511-1518



To determine the effect of ileal oleate on fasting intestinal motility, pairs of duodenal and ileal catheters and bipolar duodenal and jejunal seromuscular electrodes were surgically implanted in six dogs. The ileum was perfused with either normal saline (154 mM NaCl) or oleic acid emulsion (152 mM), while intestinal myoelectric activity was continuously monitored. For transit studies, a bolus of (3H)PEG was injected into the duodenum, and jejunal and ileal alliquots were collected every 15 min for a 6-hr study period. Plasma samples were collected for radioimmunoassays of peptide YY and enteroglucagon. Ileal oleate infusion increased the MMC cycle length and decreased the number of MMCs (P lt 0.001) and the myoelectric spike-burst frequency/10 min in the duodenum (P lt 0.05). Both duodenal-jejunal (P lt 0.05) and duodenal-ileal transit (P lt 0.01) were delayed markedly by ileal perfusion with oleic acid emulsion as compared to control studies. Ileal oleate increased plasma levels of peptide YY (P lt 0.01) and enteroglucagon (P lt 0.01). Ileal perfusion with oleate therefore activated the so-called "ileal brake", diminishing duodenal myoelectric spike bursts and slowing intestinal transit while concurrently increasing plasma levels of peptide YY and enteroglucagon.

Accession: 002356681

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PMID: 8026264

DOI: 10.1007/bf02088057

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