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Effects of ethane dimethanesulfonate (EDS) on adult and immature rabbit Leydig cells: comparison with EDS-treated rat Leydig cells

Laskey, J.W.; Klinefelter, G.R.; Kelce, W.R.; Ewing, L.L.

Biology of Reproduction 50(5): 1151-1160

1994


ISSN/ISBN: 0006-3363
PMID: 8025172
DOI: 10.1095/biolreprod50.5.1151
Accession: 002364047

Previous studies have shown that EDS selectively kills Leydig cells and depresses testosterone production in adult rats, but that immature rat Leydig cells are less sensitive to EDS. There is also evidence that rabbits metabolize EDS to methane sulphonic acid more rapidly than rats. In the present study, EDS significantly reduced serum and interstitial testosterone levels in adult rabbits.

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