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Effects of urinastatin (human urinary trypsin inhibitor) against endotoxin shock in dogs






Journal of Veterinary Anaesthesia (Special supplement): 335-346

Effects of urinastatin (human urinary trypsin inhibitor) against endotoxin shock in dogs

The therapeutic effect of urinastatin, an inhibitor of the protease activity, on endotoxin shock was evaluated using 17 Beagle dogs. Single i.v. injection of urinastatin at a dose of 5 000 or 25 000 U/kg failed to suppress the endotoxin-induced circulatory disturbance but significantly inhibited increases in pulmonary arterial pressure and pulmonary vascular resistance that occur early following administration of endotoxin.

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Accession: 002367048



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