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Estimation of thyroid inhibitor residues and histopathological changes in rabbits treated with 6-n-propyl-2-thiouracil

, : Estimation of thyroid inhibitor residues and histopathological changes in rabbits treated with 6-n-propyl-2-thiouracil. Industrie Alimentari 30(290): 124-128

In an attempt to establish criteria for identifying rabbits fed on plants containing goitrogens or fraudulently treated with thyroid inhibitors, residues and histopathological changes were studied in 3 groups of male New Zealand rabbits given feeds without or with 6-n-propyl-2-thiouracil 1000 mg/kg for 10 or 20 days. Residues were found in kidneys and liver and traces in muscle of rabbits killed 2 days after suspension of treatment.

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Related references

Bastenie, P.A.; Kowalewski, K., 1950: Effect of the thyrotropic hormone on the thyroid function of the rat treated with propyl thiouracil. Annales D'endocrinologie 11(3): 276-284

Triantaphyllidis H.; Vignal A., 1968: Ioduration of rabbit albumin injected in vivo with the thyroid of a mouse treated with propyl thiouracil. Presse Medicale 76(38): 1837

Mazzanti, L.; Franchi, M., 2014: Experimental study on the thyroid of the albino rat submitted to the associated action of x-rays and thiouracil. II. Histological and functional examination of the thyroid of the rat treated with x-rays and with thiouracil in various combinations. Radioterapia, Radiobiologia E Fisica Medica 3(4): 227-295

Berg, B.H., 1971: The reactions of mercaptopurine, 2-thiouracil, 6-methyl-2-thiouracil and 6-propyl-2-thiouracil with diphenylpicrylhydrazyl. Acta Pharmaceutica Suecica 8(4): 443-452

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