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Ethanol stimulates apo A-1 secretion in human hepatocytes: a possible mechanism underlying the cardioprotective effect of ethanol






Nutrition Reviews 51(5): 151-152

Ethanol stimulates apo A-1 secretion in human hepatocytes: a possible mechanism underlying the cardioprotective effect of ethanol

A mechanism which may underlie the cardioprotective effect of ethanol is described. The effect of ethanol on secretion of the major protein component of high density lipoproteins, apoprotein A-1 (apo A-1), was examined in cultured human hepatocytes. Apo A-1 plays an important role in reverse cholesterol transport by binding this substance in peripheral tissue and transporting it to the liver. Ethanol stimulated synthesis of apo A-1 in cultured cells. This ethanol-induced synthesis increased cholesterol efflux from cultured fibroblasts. Enhanced activity of the reverse cholesterol pathway, mediated by increased hepatic apo A-1 synthesis, may account for the relationship between ethanol consumption and the reduced incidence of coronary heart disease. .

Accession: 002373626

PMID: 8332287

DOI: 10.1111/j.1753-4887.1993.tb03093.x

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Related references

Anonymous, 1993: Ethanol stimulates apo A-1 secretion in human hepatocytes: a possible mechanism underlying the cardioprotective effect of ethanol. Ethanol stimulates synthesis of the high-density lipoprotein (HDL) protein apo A-1 in cultured human hepatocytes. This ethanol-induced secretion can increase the efflux of cholesterol from cultured fibroblasts. Enhanced activity of a reverse chole...

Amarasuriya, R.N.; Gupta, A.K.; Civen, M.; Horng, Y.C.; Maeda, T.; Kashyap, M.L., 1992: Ethanol stimulates apolipoprotein A-1 secretion by human hepatocytes: implications for a mechanism for atherosclerosis protection. Using highly specific antibodies, it was found that ethanol increases apolipoprotein (apo) A-1 secretion and the incorporation of radiolabelled leucine into apo A-1 by human hepatocytes (Hep-G2 cells). Also it was found that apo A-1 molecules indu...

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