Section 3
Chapter 2,381

Failure to develop homologous immunity to a second challenge with Leishmania (Viannia) braziliensis in the black-plumed marmoset (Callithrix penicillata)

Cuba-Cuba, C.A.; Marsden, P.D.

Transactions of the Royal Society of Tropical Medicine and Hygiene 86(1): 37


ISSN/ISBN: 0035-9203
PMID: 1566300
DOI: 10.1016/0035-9203(92)90432-c
Accession: 002380414

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Two of 5 C. penicillata that had received a 2nd homologous challenge of cultured stationary phase promastigotes (5 x 105 promastigotes of L. braziliensis) developed new skin granulomata at the challenge inoculation sites. One marmoset still had an active skin ulcer on the left ear when re-inoculated in the right ear and the base of its tail 12 months after initial infection in the left ear with stock MHOM/BR/83/LTB-300. Viable parasites were recovered both from the original left ear lesion and from the 2 secondary granulomata. The 2nd marmoset was re-inoculated with the same stock as the primary challenge (MHOM/BR/85/LTB-12) which had been given 6 months previously. The initial challenge produced a naturally healing parasite-positive granuloma on the ear, which healed after 25 weeks. The 2nd challenge produced granulomata at both inoculation sites, but parasites were recovered only from one of them.

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