+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Genes for the trophoblast interferons and their distribution among mammals

Genes for the trophoblast interferons and their distribution among mammals

Reproduction, Fertility, and Development 4(3): 349-353

The trophoblast interferons (IFN), ovine and bovine trophoblast protein-1 (oTP-1 and bTP-1 respectively), possess many properties in common with other Type I IFN, including antiviral and antiproliferative activities. However, they differ from other IFN subtypes in terms of their specific pattern of expression and poor responsiveness to viral stimulation. We describe here data that suggest that the trophoblast IFN genes are also distinct from other Type I IFN genes with respect to species distribution, promoter organization and transcriptional regulation. These results have important implications in terms of trophoblast IFN gene evolution and add credence to the concept that the trophoblast IFN genes are a distinct IFN gene subtype well suited for their role in early pregnancy.

(PDF emailed within 0-6 h: $19.90)

Accession: 002390073

Download citation: RISBibTeXText

PMID: 1438967

DOI: 10.1071/RD9920349

Related references

Genes for the trophoblast interferons in sheep, goat, and musk ox and distribution of related genes among mammals. Journal of Interferon Research 12(1): 1-11, 1992

Species distribution of genes for the trophoblast interferons and gene sequence conservation among ruminants. Journal of Interferon Research 10(SUPPL 1): S46, 1990

The genes for the trophoblast interferons and the related interferon-alpha II possess distinct 5'-promoter and 3'-flanking sequences. Journal of Biological Chemistry 266(5): 3060-3067, 1991

Cloning and structural analysis of two distinct families of ovine interferon-alpha genes encoding functional class II and trophoblast (oTP) alpha-interferons. Molecular and Cellular Endocrinology 76(1-3): 161-171, 1991

Effects of human trophoblast-induced interferons on the expression of proto-oncogenes c-fms/CSF-1R, EGF-R and c-erbB2 in invasive and non-invasive trophoblast. Placenta. 18(2-3): 155-161, 1997

Human trophoblast interferons enhance major histocompatibility complex class I antigen expression on human term trophoblast cells in culture. Placenta. 15(7): 709-714, 1994

Trophoblast interferons. Placenta 20(4): 259-264, 1999

Human trophoblast interferons. Antiviral Research. 22(2-3): 91-105, 1993

Trophoblast interferons as antiluteolysins. Edwards, R G (Ed ) Serono Symposia Publications From Raven Press, Vol 66 Establishing A Successful Human Pregnancy; Meeting, Cambridge, England, Uk Xii+288p Raven Press: New York, New York, Usa Illus 257-268, 1990

Unique features of the trophoblast interferons. Pharmacology & Therapeutics 51(3): 329-346, 1991

Progressive expression of trophoblast-specific genes during formation of mouse trophoblast giant cells in vitro. Molecular Reproduction and Development 34(4): 357-368, 1993

Functional characteristics of human trophoblast interferons. American Journal Of Reproductive Immunology. 35(4): 309-317, 1996

Cell specific expression of the trophoblast interferons. Journal of Interferon Research 11(SUPPL 1): S66, 1991

Is ovine trophoblast protein 1 related to the interferons. Biology of Reproduction 36(SUPPL 1): 50, 1987

The molecular biology of trophoblast alpha-II interferons. Animal Production 56(3): 457, 1993