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Genetic and transgenic studies of prion proteins in Gerstmann-Straussler-Scheinker disease



Genetic and transgenic studies of prion proteins in Gerstmann-Straussler-Scheinker disease



Prion diseases of humans and animals: 120-128



This paper on genetic studies of the disease in humans includes consideration of studies of neurological symptoms in transgenic mice carrying the mouse prion protein gene with a leucine substitution at codon 101 (homologous to codon 102 in humans, where substitution of leucine at this codon was found in several families affected with the disease).

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Accession: 002390409

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