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Intracarotid glucose induced norepinephrine response and the development of diet induced obesity

, : Intracarotid glucose induced norepinephrine response and the development of diet induced obesity. International Journal of Obesity and Related Metabolic Disorders 16(6): 451-457

Intracarotid glucose infusions cause increased plasma norepinephrine (NE) levels in some rats. This is used as an index of sympathetic activation. Similar increase in plasma NE levels are produced by intravenous glucose injections and these levels correlate positively with the amount of weight gained by adult rats when they are subsequently fed a diet enriched in calories, sucrose and fat (condensed milk (CM) diet) for three months. Thus, rats prone to develop diet induced obesity (DIO) on the CM diet have greater intravenous glucose induced NE responses than those which are diet resistant (DR). To test the hypothesis that this relationship is mediated by the brain, 17 chow fed, adult male Sprague-Dawley rats were infused for 60 min with intracarotid glucose at 4mg/kg/min and blood samples were obtained for plasma catecholamines, insulin and glucose. They were then placed on the CM diet for three months. After three months on the CM diet, there was a wide variability in body weight gain and the weights of retroperitoneal fat pads, an indirect measure of carcass adiposity. For all 17 rats, there was a significant correlation between both body weight gain (r=0.685, P=0.002) and retroperitoneal fat pad weights (r=0.590, P=0.013) with the levels of plasma NE reached 45-60min into the preceding intracarotid glucose infusions. For the six lowest and six highest glucose induced NE responders, the correlation between NE response and body weight gain on CM diet was r=0.944 (P=0.0001). Plasma epinephrine, insulin and glucose levels were unchanged during such infusions. Thus, glucose, acting directly on the brain, activates the sympathetic nervous system in those rats most likely to develop DIO on the CM diet. This suggests that responsiveness of the brain to glucose plays an important role in the differential body weight gain of rats exposed to diets high in calories, sucrose anf fat.

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Accession: 002416085

PMID: 1322871

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Other references

Weill, R., 1934: Contribution a l'etude des cnidaires et de leurs nematocystes. II. Valeur taxonomique du cnidome. Travaux de la Station Zoologique de Wimereux, 11: 351-701

Laporte, J.; Blondeau, F.; Buj Bello, A.; Kretz, C.; Mandel, J.L., 1999: Diagnosis of X-linked myotubular myopathy by detection of the implicated protein , and genotype/phenotype correlation in mild cases. American Journal of Human Genetics 65(4): A307, Oct

Campbell C.A.; Biederbeck V.O.; Warder F.G., 1973: Influence of simulated fall and spring conditions on the soil system part 3 effect of method of simulating spring temperatures on ammonification nitrification and microbial populations. Soil Science Society of America Proceedings 37(3): 382-386

Okamoto, H.; Sakai, K.; Murata, T.; Kataoka, T.; Hata, S., 2006: Object-oriented software framework developed for agricultural hyperspectral imaging analysis. An experiment was conducted to construct a software framework that can be used for agricultural hyperspectral image analysis. The framework is constructed based on the object-oriented design method. The users can easily develop their own specializ...

Tsai, M-Fung.; Tsai, H-Yu.; Peng, Y-Shiang.; Wang, L-Fang.; Chen, J-Shing.; Lu, S.Chun., 2007: Characterization of hydrogels prepared from copolymerization of the different degrees of methacrylate-grafted chondroitin sulfate macromers and acrylic acid. Different degrees (between 20 and 75%) of methacrylate-grafted chondroitin sulfate (CS-MA) were synthesized. These CS-MA macromers were further copolymerized with acrylic acid (AA) at the molar ratio of 1 to 5 to form hydrogels. The sol percents o...

Moiseev, EV., 1990: Distribution of nanoheterotrophic organisms in the Peruvian upwelling area. Unknown

Hudson, PJ.; Dobson, AP., 1991: The direct and indirect effects of the caecal nematode Trichostrongylus tenuis on red grouse. Oxford Ornithology Series, 49-68 No. 2

Xu, G. H.; Bao, S. D.; Yang, J. P.; Wu, M., 1995: The relationship between potassium absorption ability and root parameters in different crops. In pot trials with 3 soils differing in K contents, wheat and Vicia sativa were grown with or without application of 0.1 g K/kg soil. Wheat had a greater ability to use soil non-exchangeable K and a higher rate of use of applied K. The total and a...

Monsaingeon A.; Thomas J.; Raverdy P., 1968: Neurologic form of a neopl parathyroid adenoma abstract human. Presse Medicale 76(18): 876

Tachiki H.; Kumamoto Y.; Nanbu A.; Itoh N.; Mikuma N.; Takagi Y.; Tsukamoto T.; Maruta H.; Ohsawa N., 1991: Prostatic fluid polyamine levels as a marker of prostatic function. Prostatic fluid polyamine levels were measured by simple enzymatic assay. Our data of split ejaculation indicates that seminal polyamine originates from the prostate. A close correlations were found among polyamine, zinc and magnesium levels in pr...