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Intracellular mechanisms involving gonadotropin and growth hormone release in the goldfish, Carassius auratus






Fish Physiology and Biochemistry 11(1-6): 25-33

Intracellular mechanisms involving gonadotropin and growth hormone release in the goldfish, Carassius auratus

Evidence for the involvement of Ca2+, protein kinase C, cAMP and arachidonic acid metabolism in the mediation of gonadotropin (GTH) and growth hormone (GH) release in the goldfish is reviewed, and models for the signal transduction pathway mediating GnRH and dopamine actions on GTH and GH secretion are postulated. A novel hypothesis, suggesting that two GnRHs which bind to the same receptor type activate different transduction cascades in 2 different cell types (GTH vs.


Accession: 002416106



Related references

Chang, J.P.; Jobin, R.M.; Wong, A.O., 1993: Intracellular mechanisms mediating gonadotropin and growth hormone release in the goldfish, Carassius auratus. Evidence for the involvement of Ca(2+), protein kinase C, cAMP, and arachidonic acid metabolism in mediating gonadotropin (GTH) and growth hormone (GH) release in the goldfish is reviewed. Models for the signal transduction pathways mediating GTH-...

Murthy, C.K.; Wong, A.O.; Habibi, H.R.; Rivier, J.E.; Peter, R.E., 1994: Receptor binding of gonadotropin-releasing hormone antagonists that inhibit release of gonadotropin-II and growth hormone in goldfish, Carassius auratus. In goldfish, GnRH stimulates gonadotropin-II (GTH-II) and growth hormone (GH) release. The two native forms of GnRH, salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), bind to two classes of GnRH binding sites: high-affinity/low-capacity sites an...

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Murthy, C.K.; Turner, R.J.; Wong, A.O.; Rao, P.D.; Rivier, J.E.; Peter, R.E., 1994: Differential actions of a mammalian gonadotropin-releasing hormone antagonist on gonadotropin-II and growth hormone release in goldfish, Carassius auratus. In goldifish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1...

Klausen, C.; Chang, J.P.; Habibi, H.R., 2001: The effect of gonadotropin-releasing hormone on growth hormone and gonadotropin subunit gene expression in the pituitary of goldfish, Carassius auratus. The goldfish brain contains at least two forms of gonadotropin-releasing hormone (GnRH): sGnRH and cGnRH-II. In goldfish sGnRH and cGnRH-II are present both in the brain and pituitary, and exert direct effects via specific GnRH receptors stimulati...

Murthy, C.K.; Zheng, W.; Trudeau, V.L.; Nahorniak, C.S.; Rivier, J.E.; Peter, R.E., 1994: In vivo actions of gonadotropin-releasing hormone (GnRH) antagonist on gonadotropin-II and growth hormone secretion in goldfish, Carassius auratus. In the authors' previous in vitro studies, [Ac- Delta superscript 3-Pro1, 4FD-Phesuperscript 2, D-Trp3,6]-mGnRH (analogue E) suppressed both gonadotropin-II (GTH-II) and growth hormone (GH) release stimulated by sGnRH and cGnRH-II. In the pre...

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Chang J.P.; Mackenzie D.S.; Gould D.R.; Peter R.E., 1984: Effects of dopamine and norepinephrine on in vitro spontaneous and gonadotropin releasing hormone induced gonadotropin release by dispersed cells or fragments of the goldfish carassius auratus pituitary. Enzymatically dispersed goldfish pituitary cells or freshly prepared goldfish pituitary fragments continue to secrete gonadotropin spontaneously in a column perifusion system. After the establishment of basal secretion rates, treatment of disperse...

Omeljaniuk, R.J.; Tonon, M.C.; Peter, R.E., 1989: Dopamine inhibition of gonadotropin and alpha -melanocyte- stimulating hormone release in vitro from the pituitary of the goldfish (Carassius auratus). The receptor specificity of dopamine inhibition of gonadotropin (GtH) and alpha -melanocyte-stimulating hormone ( alpha -MSH) release from the goldfish pituitary were studied in vitro. The results suggested the involvement of a low-affinity dopami...