+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Intragastric tryptophan reduces glycemia after glucose, possibly via glucose-mediated insulinotropic polypeptide, in early-weaned piglets

, : Intragastric tryptophan reduces glycemia after glucose, possibly via glucose-mediated insulinotropic polypeptide, in early-weaned piglets. Journal of Nutrition 124(2): 259-267

The aim of this experiment was to investigate the influence of oral tryptophan on insulin, glucose-mediated insulinotropic polypeptide and glucose concentrations in early-weaned piglets. Piglets were given by intragastric infusion, at the same level of feeding, either a tryptophan-deficient or tryptophan-adequate diet for 22 d. During the experiment blood samples were taken after intragastric infusion of 1) the accustomed meal, 2) a glucose plus tryptophan load and 3) a glucose load. Plasma samples were analyzed for insulin, glucose-mediated insulinotropic polypeptide, glucose and lactate. After the accustomed meal plasma insulin concentrations were augmented and liquid gastric emptying faster in pigs fed tryptophan-adequate compared with tryptophan-deficient diets (P < 0.05) but glucose-mediated insulinotropic polypeptide, glucose and lactate were unaffected. The addition of tryptophan to a glucose load increased glucose-mediated insulinotropic polypeptide and reduced glucose in both tryptophan-adequate and tryptophan-deficient diet fed pigs (P < 0.05). Piglets adapted to the tryptophan-adequate diet had a greater glucose-mediated insulinotropic polypeptide response to intragastric glucose plus tryptophan than piglets adapted to the tryptophan-deficient diet. Adaptation to a tryptophan-adequate diet seems to increase the release of glucose-mediated insulinotropic polypeptide due to infusion of a tryptophan-adequate compared with a tryptophan-deficient diet. The addition of tryptophan to a glucose load reduces the level of glycemia, possibly through glucose-mediated insulinotropic polypeptide-mediated glucose disposal.

Accession: 002416145

PMID: 8308575

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Tseng, C.C.; Kieffer, T.J.; Jarboe, L.A.; Usdin, T.B.; Wolfe, M.M., 1996: Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat. Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid peptide produced by K cells of the mammalian proximal small intestine and is a potent stimulant of insulin release in the presence of hyperglycemia. However, its relative physio...

Krarup, T.; Vilsboll, T.; Madsbad, S.; Holst, J.J., 2003: Both glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide contributes to the insulinotropic effect at basal and postprandial glucose levels in healthy subjects. Diabetologia 46(Supplement 2): A201, August

Lewis, J.T.; Dayanandan, B.; Habener, J.F.; Kieffer, T.J., 2000: Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. A novel GIP receptor antagonist was developed to evaluate the acute role of glucose-dependent insulinotropic polypeptide (GIP) in the insulin response to oral glucose in rats. Antisera to an extracellular epitope of the GIP receptor (GIPR) detecte...

Lee, M.Y.; Fraser, J.D.; Chapman, M.J.; Sundararajan, K.; Umapathysivam, M.M.; Summers, M.J.; Zaknic, A.V.; Rayner, C.K.; Meier, J.J.; Horowitz, M.; Deane, A.M., 2014: The effect of exogenous glucose-dependent insulinotropic polypeptide in combination with glucagon-like peptide-1 on glycemia in the critically ill. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have additive insulinotropic effects when coadministered in health. We aimed to determine whether GIP confers additional glucose-lowering to that of GLP-1 in th...

Aumaitre, A.M.lcion, J.; Vaissade,, B., 1978: Use of glucose, fructose rich glucose syrup or sucrose in diets of early weaned piglets: influence on pelleting and palatability. Annales de zootechnie7(3): 409-421

Aumaitre, A.; Melcion, J.P.; Vaissade, P.; Seve, B., 1978: Use of glucose fructose rich glucose syrup or sucrose in diets of early weaned piglets influence on feed pelleting and palatability. The effect of incorporating sweet substances (HFCS) into piglet feeds on palatability was measured during 4 experiments using 252 animals weaned at 35 days and 80 animals weaned at 21 days. The incorporation of sucrose reduced the pelleting yield...

Irwin, N.; Green, B.D.; Gault, V.A.; Harriot, P.; O'Harte, F.P.M.; Flatt, P.R., 2005: Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice. Glucose tolerance progressively declines with age whilst the onset of type two diabetes increases dramatically. Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion. The present study was designed to ass...

Mabilleau, G.; Perrot, R.; Mieczkowska, A.; Boni, Sébastien.; Flatt, P.R.; Irwin, N.; Chappard, D., 2016: Glucose-dependent insulinotropic polypeptide (GIP) dose-dependently reduces osteoclast differentiation and resorption. A role for glucose-dependent insulinotropic polypeptide (GIP) in controlling bone resorption has been suspected. However uncertainty remains to identify whether GIP act directly on osteoclasts. The aim of the present study were (i) to identify in...

Shimada, M.; Mochizuki, K.; Goda, T., 2010: Dietary resistant starch reduces histone acetylation on the glucose-dependent insulinotropic polypeptide gene in the jejunum. We have reported that dietary resistant starch (RS) reduces glucose-dependent insulinotropic polypeptide (GIP) mRNA levels along the jejunoileum in both normal and diabetic rats. In this study, we found that jejunal reduction of the GIP gene by fe...

Hansen, L.; Orskov, C.; Rickelt, L.; Holst, J.J., 1999: Is carbohydrate and lipid stimulated GLP-1 secretion mediated by glucose-dependent insulinotropic polypeptide ?. Diabetes 48(SUPPL 1): A200