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Intravenous glucose tolerance test-derived glucose effectiveness in physically trained humans

, : Intravenous glucose tolerance test-derived glucose effectiveness in physically trained humans. American Journal of Physiology 265(2 Pt 1): E298-E303

Glucose effectiveness (S-G) and insulin sensitivity of sedentary and physically trained males were estimated by the minimal model approach. Trained subjects, who ran 86 +- 10 km/wk and had 37% higher maximal oxygen consumption than that of sedentary subjects (56.2 +- 1.2 vs. 40.9 +- 1.4 ml cntdot kg-1 cntdot min-1, P lt 0.01), were studied 16 h and 1 wk after their last training session. After overnight fasting, glucose was administered intravenously (300 mg/kg body wt) within 2 min, and insulin was infused ( apprx 13-20 mU/kg given over 5 min) from 20 to 25 min after administration of glucose. Glucose disappearance constant values as an estimate of glucose tolerance were significantly higher in trained subjects after 16 h and 1 wk of their training session (3.29 +- 0.48 and 3.60 +- 0.64%/min) than in sedentary subjects (1.92 +- 0.30%/min, P lt 0.05). Insulin sensitivity in trained subjects measured after 16 h and 1 wk of their last training session (26.2 +- 4.4 and 24.3 +- 6.0 times 10-5 min-1 cntdot pM-1) was also higher than that of sedentary subjects (10.3 +- 1.2 times 10-5 min-1 cntdot pM-1, P lt 0.05). S-G, the ability of glucose itself to increase peripheral glucose uptake and suppress hepatic glucose output, was significantly higher in trained subjects after 16 h and 1 wk of their last training session (0.028 +- 0.003 and 0.030 +- 0.004/min) than in sedentary subjects (0.017 +- 0.002/min, P lt 0.05). Non-insulin-dependent component of S-G (GEZI) was higher in trained subjects after 16 h and 1 wk of their last training session (0.021 +- 0.003, 0.023 +- 0.003/min) than sedentary subjects (0.013 +- 0.002/min, P lt 0.05). However, the basal insulin component of S-G was similar among the three groups (0.007 +- 0.003 and 0.007 +- 0.002/min for trained subjects 16 h and 1 wk after their last training session and 0.004 +- 0.001/min for sedentary subjects, P gt 0.05). Thus S-G, particularly GEZI, is higher in trained subjects than in sedentary subjects.

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Accession: 002416295

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