EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Intravenous intralipid 10% vs. 20%, hyperlipidemia, and increase in lipoprotein X in humans






Nutrition 8(3): 155-160

Intravenous intralipid 10% vs. 20%, hyperlipidemia, and increase in lipoprotein X in humans

To clarify mechanisms of hyperlipidaemia caused by infusion of Intralipid 10%, lipoprotein metabolism during intravenous Intralipid 10 and Intralipid 20% (which contains half the amount of egg yolk lecithin for the same content of triacylglycerol as Intralipid 10%) was compared. 10 patients (7 men, 3 women, 56.6+or-8.8 years old) receiving Intralipid 10% 20 ml/kg daily and 10 (8 men, 2 women; 52.8+or-15.1 years old) receiving Intralipid 20% 10 ml/kg daily were fed exclusively by total parenteral nutrition (TPN) providing amino acid 1.1 g and 30 kcal/kg daily for 4-6 weeks. Intravenous Intralipid 10% caused a marked increase in low-density lipoprotein (LDL), and increases in phospholipid and cholesterol, especially free cholesterol. The progressive increase in lipoprotein X (LpX) was in proportion with that of LDL or total lipid, whereas no increase in lipids, LDL, or LpX was observed during intravenous Intralipid 20%. A significant increase in apolipoproteins CIII and E with Intralipid 10% also caused a rise in LpX. With Intralipid 20%, however, alterations in apolipoproteins were not observed. Lecithin:cholesterol acyltransferase (LCAT) activity was significantly elevated with Intralipid 10 but not 20%. Disappearance of LpX after cessation of Intralipid 10% was relatively rapid, and the half-life was 24-60 h. From the findings, hyperlipidaemia with Intralipid 10% was caused almost exclusively by the increase in LpX. The excess lecithin may be responsible for the formation of an increase in LpX. It was observed that Intralipid 20% could be safely used without inducing hyperlipidaemia.


Accession: 002416304

PMID: 1525430



Related references

Intravenous fat emulsion intralipid induces increase of lipoprotein lipase activity in term newborns. Pediatric Research 20(4 PART 2): 250A, 1986

The metabolic and cardiovascular effects of intravenous infusion of glucose or intralipid in normal humans. Clinical Nutrition (Edinburgh) 8(3): 135-140, 1989

Changes of high density lipoprotein subfraction concentration and composition by intralipid in vivo and by lipolysis of intralipid in vitro. Arteriosclerosis 3(6): 607-615, 1983

The intravenous fat tolerance test with intralipid in various types of hyperlipidaemias and comparison between metabolism of intralipid and VLDL. Advances in Experimental Medicine and Biology 38: 69-85, 1973

Effects of intravenous infusions of commercial fat emulsions (Intralipid 10 or 20%) on rat plasma lipoproteins: phospholipids in excess are the main precursors of lipoprotein-X-like particles. Biochimica et Biophysica Acta L, Lipids and Lipid Metabolism 1047(2): 121-130, 1990

Increased lipoprotein X causes hyperlipidemia during intravenous administration of 10% fat emulsion in man. Jpen. Journal of Parenteral and Enteral Nutrition 15(5): 546-550, 1991

Effects of intravenous infusions of commercial fat emulsions intralipid 10 or 20 percent on rat plasma lipoproteins phospholipids in excess are the main precursors of lipoprotein x like particles. Biochimica et Biophysica Acta 1047(2): 121-130, 1990

Lack of compensatory increase in high density lipoprotein hyperlipidemia due to lipoid nephrosis. Journal of the American Society of Nephrology 2(3): 275, 1991

Treatment of primary mixed hyperlipidemia with etophylline clofibrate: Effects on lipoprotein-modifying enzymes, postprandial lipoprotein metabolism, and lipoprotein distribution and composition. Atherosclerosis 117(2): 253-261, 1995

Studies on the heredity and pathogenesis of familial combined hyperlipidemia ("multiple lipoprotein type" hyperlipidemia). Schweizerische Medizinische Wochenschrift 106(39): 1301-1312, 1976