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Invertebrate neuropeptides resembling vasotocin and some analogues: synthesis and pharmacological properties


Experientia (Basel): 467: 771-773
Invertebrate neuropeptides resembling vasotocin and some analogues: synthesis and pharmacological properties
The solid phase synthesis of three invertebrate vasopressin-oxytocin homologs: AVP-like factor, F11, ([Leu2, Thr4] AVT)2 isolated from subesophageal and thoracic ganglia of Locusta migratoria3, Arg-conopressin-S4. ([Ile2, Arg4] AVT), Lys-conopressin-G4 ([Phe2, Arg4] LVT), both isolated from the venom of fish-hunting marine snails of the genus Conus and six of their analogues is reported. These analogues are: [Arg4] AVT, [Ile2] AVT, [Leu2] AVT, [Phe2, Arg4] AVT, [Arg4] LVt and [ILe2, Arg4] LVT. All peptides were tested for antidiuretic and vasopressor activities.

Accession: 002416668

PMID: 2373207

DOI: 10.1007/bf01939964

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