EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Investigation of glomerular lesions in dogs with acute experimentally induced Ehrlichia canis infection


, : Investigation of glomerular lesions in dogs with acute experimentally induced Ehrlichia canis infection. American Journal of Veterinary Research 53(12): 2286-2291

Six male Beagles were inoculated with Ehrlichia canis. Transient proteinuria was confirmed during the acute phase of infection by serial determination of urinary protein-to-creatinine ratio. Peak urine protein loss, consisting principally of albumin, was observed 2.5 to 3.5 weeks after inoculation. Renal biopsy specimens were obtained before inoculation, during peak proteinuria, and 10 weeks after inoculation when proteinuria had resolved. Renal tissue was evaluated by use of light, immunofluorescent, and electron microscopy to correlate specific glomerular lesions with development of proteinuria. Histologic examination revealed perivenular and interstitial infiltrates of lymphocytes and plasma cells localized principally to the renal cortex. Glomerular lesions were minimal to absent. Immunofluorescent staining revealed moderate to marked deposition of anti-canine IgG and IgM in the glomerular tufts and mesangium. Depositions of anti-canine complement factor C3 were not observed. Immunofluorescent staining persisted 10 weeks after inoculation, despite resolution of proteinuria, and probably represented passive trapping of immunoglobulins. Ultrastructural examination revealed fusion of podocyte processes that coincided with development of proteinuria. Electron-dense deposits or changes in the basement membrane were not observed. Morphometric measurements of average podocyte process length and percentage of coverage of basement membrane by podocyte processes were used to quantify the degree of process fusion. Both measurements increased significantly (P < 0.05) during peak proteinuria, and returned to preinoculation values when proteinuria had resolved 10 weeks after E canis inoculation. These findings indicated possible minimal-change glomerulopathy, rather than immune-complex glomerulonephritis, during acute E canis infection and could explain transient proteinuria without histologic evidence of glomerular disease.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002416809

PMID: 1476309

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Lambrecht, L.; Baele, G.; Barbier, F., 1987: Hemostatic alterations in Crohn's disease. Thromboembolic disease is a known complication of inflammatory bowel disease, and especially of ulcerative colitis, but is less frequently reported in Crohn's disease. In this study, we have determined 16 coagulation parameters in 20 consecut...

Murad, T.M., 1971: Cytologic differentiation of carcinoma of the breast by electron microscopy. Acta Cytologica 15(4): 400-409

Omang, S. H.; Vellar, O. D., 1973: Analytical error due to concentration gradients in frozen and thawed samples. A table shows concentrations of Ca, Cu and Na in serum and sweat and of Ca and Na in urine, estimated by atomic absorption spectrometry in those fluids thawed without shaking. Values were very low in samples taken from the top layer and about doub...

Cabezas-Herrera, J.; Campoy, F.J.; Vidal, C.J., 1993: Molecular forms of acetylcholinesterase in microsomal membranes of normal and dystrophic muscle. Biochemical Society Transactions 21(2): 108s-108s

Coggins, D.L.; Lee, R.J.; Sweeney, J.; Chein, W.W.; Van Hare, G.; Epstein, L.; Gonzalez, R.; Griffin, J.C.; Lesh, M.D.; Scheinman, M.M., 1994: Radiofrequency catheter ablation as a cure for idiopathic tachycardia of both left and right ventricular origin. Objectives. The purpose of this study was 1) to investigate the efficacy and safety of radiofrequency energy catheter ablation as curative treatment for idiopathic tachycardia of both left and right ventricular origin, and 2) to compare the useful...

Atkins, Dianne L.; Klewer, Scott E.; Behrendt, Douglas M.; Moller, James H., 1996: Infant truncus arteriosus repair The pediatric cardiac care consortium experience. Pediatrics 98(3 PART 2): 524-525

WALKER, S.A.; BENDITT, E.P., 1948: An electrophoretic study of the serum proteins in scleroderma. Electrophoretic analysis of the serum proteins of 5 patients with diffuse scleroderma show a decrease in albu- min and an increase in the gamma globulin fraction, with no change in total proteins. Similar values were obtained in one case of locali...

Widler, W., 1976: Berries in the family garden. Grune 104 (10) 25-30

Anonymous, 1981: Nutrition and management of female broiler breeding stock. This factorial experiment involved 2 strains, early and late maturity (depending on nutrition and light regime), and 2 energy levels during the laying period. Hubbard birds produced significantly more eggs than Ross birds per hen present initially...

Frolov-Yu, M., 1977: Variations in morphological and biological characteristics of the prickly comfrey in its northward movement. Georaphical variation and morphological characteristics of 5 yr old Symphytum asperum (used as cattle feed) were compared from various areas of northern Syktyvkar and southern Kiev USSR. Increased shoot formation, less shoot leaves, greater leaf n...